Evidence map›Paper›PMID 30773377›Full record

ReviewUltrasound in medicine & biology2019

Ultrasound Hyperthermia Technology for Radiosensitization.

Lifei Zhu, Michael B Altman, Andrei Laszlo, William Straube, Imran Zoberi, Dennis E Hallahan, Hong Chen

Open access · greenAbstract readReview
In one paragraph

Review in Ultrasound in medicine & biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 120 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Focused ultrasound for brain metastases.Neuro-oncology advances · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Exploring the molecular mechanism of cancer radiosensitization: the impact of physical stimulation therapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  10. Review
  11. Review
  12. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. MR Imaging-Guided Focused Ultrasound for Breast Tumors.Magnetic resonance imaging clinics of North America · 2024
    Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lifei ZhuDepartment of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Michael B AltmanDepartment of Radiation Oncology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Andrei LaszloDepartment of Radiation Oncology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
William StraubeDepartment of Radiation Oncology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Imran ZoberiDepartment of Radiation Oncology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Dennis E HallahanDepartment of Radiation Oncology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Hong ChenDepartment of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, Missouri, USA; Department of Radiation Oncology, Washington University in Saint Louis, Saint Louis, Missouri, USA. Electronic address: hongchen@wustl.edu.
Washington University in St. Louis · US

Funding

Image-guided focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)R01EB027223 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2019 to 2026
$4.3M
FOCUS: FUNCTIONAL OPTICAL IMAGING FEEDBACK-CONTROLLED CELLULAR-LEVEL ULTRASOUND STIMULATIONR01MH116981 · NIMH · WASHINGTON UNIVERSITY · PI CHEN, HONG · 2018 to 2021
$2.8M
NIBIB NIH HHS R01 EB027223NIMH NIH HHS R01 MH116981
6 · The paper itself

Abstract

Hyperthermia therapy (HT) raises tissue temperature to 40-45°C for up to 60 min. Hyperthermia is one of the most potent sensitizers of radiation therapy (RT). Ultrasound-mediated HT for radiosensitization has been used clinically since the 1960s. Recently, magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU), which has been approved by the United States Food and Drug Administration for thermal ablation therapy, has been adapted for HT. With emerging clinical trials using MRgHIFU HT for radiosensitization, there is a pressing need to review the ultrasound HT technology. The objective of this review is to overview existing HT technology, summarize available ultrasound HT devices, evaluate clinical studies combining ultrasound HT with RT and discuss challenges and future directions.

Indexed as

Radiation ToleranceHigh-Intensity Focused Ultrasound AblationHumansHyperthermia, InducedMagnetic Resonance Imaging, InterventionalNeoplasmsUltrasonographyCancerHyperthermiaMagnetic resonance-guided high-intensity focused ultrasoundMagnetic resonance thermometryRadiosensitizationRadiotherapyUltrasound

Identifiers

PMID30773377
PMCPMC6475527
OpenAlexW2912648193

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.