Evidence map›Paper›PMID 30772922›Full record

ArticleCardiology and therapy2019

Dynamic Piston Function of the Mitral Annulus to Assess Early Left Ventricular Diastolic Filling: A Proof of Concept Study.

Dagmar F Hernandez-Suarez, Francisco López Menéndez, Angel López-Candales

Abstract read
In one paragraph

Article in Cardiology and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dagmar F Hernandez-SuarezCardiovascular Medicine Division, University of Puerto Rico School of Medicine, San Juan, PR, USA.
Francisco López MenéndezDivision of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Angel López-CandalesCardiovascular Medicine Division, University of Puerto Rico School of Medicine, San Juan, PR, USA. angel.lopez17@upr.edu.

Funding

Hispanics in Research Capability: SoHP & SOM Partnership (HIREC)S21MD001830 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ELIAS BONETA, AUGUSTO R, ESTAPE, ESTELA S · 2005 to 2010
$30.0M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., NOBOA, CARIAMARIE · 2012 to 2018
$23.2M
Hispanic Clinical and Translational Research Education and Career Development ProgramR25MD007607 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Karen G. Martinez Gonzalez, Barbara Segarra-Vazquez · 2012 to 2026
$7.4M
Conduits: MSHS Translational Science HubTL1TR001434 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GABRILOVE, JANICE L · 2015 to 2019
$2.1M
National Institutes of Health R25MD007607National Institutes of Health S21MD001830National Institutes of Health TL1TR001434-3National Institutes of Health U54MD007587NCATS NIH HHS TL1 TR001434NIMHD NIH HHS R25 MD007607NIMHD NIH HHS S21 MD001830NIMHD NIH HHS U54 MD007587
6 · The paper itself

Abstract

introductionEarly left ventricular (LV) filling has been described as an asymmetric toroidal vortex ring of blood entering the LV upon opening of the mitral valve. This phenomenon is in part responsible for cyclical changes in LV volumes during the cardiac cycle and also contributes to the apical and basal longitudinal displacements of the mitral annulus (MA). Although MA early diastolic (e') velocities have been used to assess early LV filling characteristics, accurate distinction between normal aging and pathological diastolic dysfunction (DD) might be challenging at times.

methodsIn this pilot study, echocardiographic data from 60 consecutive patients were reviewed. The studied population was allocated into three groups based on the new American Society of Echocardiography guidelines for diastolic dysfunction classification. To better define LVDD, we based our interpretation of MA tissue Doppler imaging (TDI) signals on the well-described displacement pump mechanism of the MA plane functioning as a piston unit.

resultsPatients with normal diastolic function were younger (50 ± 14 years) than those with DD (group II: 69 ± 8 and group III: 63 ± 17 years) (p < 0.001) with a slight female predominance (57%). As expected, volumetric variables as well as mitral inflow and MA TDI measures were significantly different among the three studied groups (p < 0.001) with the exception of the left atrial volume index. Interestingly, careful interrogation of the MA TDI signal revealed a distinctive appearance of a recoil signal right after the MA e' velocity only occurring in patients with normal LV diastolic function.

conclusionsIdentification of an early characteristic recoil signal occurring on the MA TDI right after the e' velocity seems to be useful in the characterization of LVDD. Additional prospective studies are now needed to validate its utility as an additional criterion to be used in LVDD.

Indexed as

Diastolic functionMitral annulus displacementRecoil signalTissue Doppler imaging

Identifiers

PMID30772922
PMCPMC6525212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.