Evidence map›Paper›PMID 30772498›Full record

ArticlePapillomavirus research (Amsterdam, Netherlands)2019

Whole tissue cervical mapping of HPV infection: Molecular evidence for focal latent HPV infection in humans.

Anne Hammer, Maurits Nc de Koning, Jan Blaakaer, Torben Steiniche, John Doorbar, Heather Griffin, Else Mejlgaard, Hans Svanholm, Wim Gv Quint, Patti E Gravitt

Open access · goldAbstract readCase Reports
In one paragraph

Article in Papillomavirus research (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Cervical Health in Systemic Lupus Erythematosus.Women's health reports (New Rochelle, N.Y.) · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. HPV and the Risk of HIV Acquisition in Women.Frontiers in cellular and infection microbiology · 2022
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Anne HammerDepartment of Obstetrics and Gynecology, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark. Electronic address: ahlauridsen@clin.au.dk.
Maurits Nc de KoningDDL Diagnostic Laboratory, Rijswijk, the Netherlands.
Jan BlaakaerDepartment of Obstetrics and Gynecology, Odense University Hospital, Denmark.
Torben SteinicheDepartment of Clinical Medicine, Aarhus University, Denmark; Department of Pathology, Aarhus University Hospital, Denmark.
John DoorbarDepartment of Pathology, University of Cambridge, United Kingdom.
Heather GriffinDepartment of Pathology, University of Cambridge, United Kingdom.
Else MejlgaardDepartment of Pathology, Aarhus University Hospital, Denmark.
Hans SvanholmDepartment of Pathology, Randers Hospital, Denmark.
Wim Gv QuintDDL Diagnostic Laboratory, Rijswijk, the Netherlands.
Patti E GravittDepartment of Global Health, Milken Institute School of Public Health, the George Washington University, USA.
Aarhus University · DKDDL Diagnostic Laboratory · NLUniversity of Cambridge · GBAarhus University Hospital · DKGeorge Washington University · USOdense University Hospital · DKRegional Hospital Randers · DK

Funding

Medical Research Council MC_PC_13050Medical Research Council MR/S024409/1
6 · The paper itself

Abstract

In this study, we aimed to provide molecular evidence of HPV latency in humans and discuss potential challenges of conducting studies on latency. We analyzed the entire cervix of two women who underwent hysterectomy unrelated to cervical abnormality. The cervices were sectioned into 242 and 186 sets respectively, and each set was tested separately for HPV using the SPF10-PCR-DEIA-LiPA25 system. To identify whether there was any evidence of transforming or productive infection, we used the biomarkers E4 and P16

Indexed as

AgedCarrier StateCervix UteriFemaleHumansMiddle AgedPapillomaviridaePapillomavirus InfectionsHPVHumansMolecular biologyPapillomavirusUterine cervical neoplasmVirus latency

Identifiers

PMID30772498
PMCPMC6389775
OpenAlexW2911643286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.