Local immunodeficiency: Minimal networks and stability.

Leonid Bunimovich, Longmei Shu

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In one paragraph

Article in Mathematical biosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 49% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Leonid BunimovichSchool of Mathematics, Georgia Institute of Technology, Atlanta, GA 30332-0160, USA. Electronic address: bunimovh@math.gatech.edu.

Longmei ShuSchool of Mathematics, Georgia Institute of Technology, Atlanta, GA 30332-0160, USA. Electronic address: lshu6@gatech.edu.

Georgia Institute of Technology · US

Funding

QUBBD: VIRAL EVOLUTION AND SPREAD OF INFECTIOUS DISEASE IN COMPLEX NETWORK: BIG DATA ANALYSIS AND MODELINGR01EB025022 · NIBIB · GEORGIA STATE UNIVERSITY · PI SKUMS, PAVEL, VANNBERG, FREDRIK · 2017 to 2019

$891k

NIBIB NIH HHS R01 EB025022

6 · The paper itself

Abstract

Some basic aspects of the recently discovered phenomenon of local immunodeficiency (Skums et al. [1]) generated by antigenic cooperation in cross-immunoreactivity (CR) networks are investigated. We prove that local immunodeficiency (LI) that is stable under perturbations already occurs in very small networks and under general conditions on their parameters. Therefore our results are applicable not only to Hepatitis C where CR networks are known to be large (Skums et al. [1]), but also to other diseases with CR. A major necessary feature of such networks is the non-homogeneity of their topology. It is also shown that one can construct larger CR networks with stable LI by using small networks with stable LI as their building blocks. Our results imply that stable LI occurs in networks with quite general topology. In particular, the scale-free property of a CR network, assumed in Skums et al. [1], is not required.

Indexed as

Models, BiologicalAntigen-Antibody ReactionsHepatitis CHumansImmune System DiseasesImmunityCross-immunoreactivity networkLocal immunodeficiencyMinimal stable network

Identifiers

PMID30772457

DOI10.1016/j.mbs.2019.02.002

PMCPMC6474679

OpenAlexW2887709353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.