Evidence map›Paper›PMID 30772363›Full record

SynthesisSurvey of ophthalmology

Automated detection of age-related macular degeneration in color fundus photography: a systematic review.

Emma Pead, Roly Megaw, James Cameron, Alan Fleming, Baljean Dhillon, Emanuele Trucco, Thomas MacGillivray

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
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  10. Extracting full information from OCT scans-signs of early age-related macular degeneration within inner retinal layers by local neighbourhood statistics. Part II: Results.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  11. Extracting full information from OCT scans-signs of early age-related macular degeneration within inner retinal layers by local neighbourhood statistics. Part I: Methodology.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  12. Ensemble learning for retinal disease recognition under limited resources.Medical & biological engineering & computing · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Emma PeadVAMPIRE Project, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland. Electronic address: s1114329@sms.ed.ac.uk.
Roly MegawPrincess Alexandra Eye Pavilion, Edinburgh, Scotland.
James CameronMRC Human Genetics Unit, The University of Edinburgh, Edinburgh, Scotland.
Alan FlemingOptos plc, Queensferry House, Carnegie Campus, Dunfermline.
Baljean DhillonPrincess Alexandra Eye Pavilion, Edinburgh, Scotland.
Emanuele TruccoVAMPIRE Project, Computing (School of Science and Engineering), University of Dundee, UK.
Thomas MacGillivrayVAMPIRE Project, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland.
University of Edinburgh · GBPrincess Alexandra Eye Pavilion · GBUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rising prevalence of age-related eye diseases, particularly age-related macular degeneration, places an ever-increasing burden on health care providers. As new treatments emerge, it is necessary to develop methods for reliably assessing patients' disease status and stratifying risk of progression. The presence of drusen in the retina represents a key early feature in which size, number, and morphology are thought to correlate significantly with the risk of progression to sight-threatening age-related macular degeneration. Manual labeling of drusen on color fundus photographs by a human is labor intensive and is where automatic computerized detection would appreciably aid patient care. We review and evaluate current artificial intelligence methods and developments for the automated detection of drusen in the context of age-related macular degeneration.

Indexed as

Diagnostic Techniques, OphthalmologicalAlgorithmsHumansImage Processing, Computer-AssistedMacular DegenerationPhotographyRetinal Drusenage-related disordersage-related macular degenerationartificial intelligencedeep learningmachine learning

Identifiers

PMID30772363
PMCPMC6598673
OpenAlexW2912072952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.