Evidence map›Paper›PMID 30772307›Full record

ArticleEBioMedicine2019

Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice.

Oren Rom, Guan Xu, Yanhong Guo, Yunhao Zhu, Huilun Wang, Jifeng Zhang, Yanbo Fan, Wenying Liang, Haocheng Lu, Yuhao Liu and 7 more

Open access · goldAbstract read
In one paragraph

Article in EBioMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Therapeutic targeting of the cGAS-STING pathway in human disease.The Journal of clinical investigation · 2026
    Review
  3. Article
  4. Article
  5. Resolvin D1-mediated cellular crosstalk protects against MASH.JHEP reports : innovation in hepatology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Mouse Models for the Study of Liver Fibrosis RegressionJournal of clinical and translational hepatology · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. SLAMF1 is expressed and secreted by hepatocytes and the liver in nonalcoholic fatty liver disease.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Oren RomDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Guan XuDepartment of Radiology, Michigan Medicine, Ann Arbor, MI, USA.
Yanhong GuoDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Yunhao ZhuDepartment of Radiology, Michigan Medicine, Ann Arbor, MI, USA.
Huilun WangDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Jifeng ZhangDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Yanbo FanDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Wenying LiangDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Haocheng LuDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Yuhao LiuDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Michael AviramThe Lipid Research Laboratory, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Zhipeng LiuDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.
Seongho KimBiostatistics Core, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Wanqing LiuDepartment of Pharmaceutical Sciences and Pharmacology, Wayne State University, Detroit, MI, USA.
Xueding WangDepartment of Radiology, Michigan Medicine, Ann Arbor, MI, USA.
Y Eugene ChenDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Luis VillacortaDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA. Electronic address: luisvill@med.umich.edu.
Michigan Medicine · USWayne State University · USPurdue University West Lafayette · USTechnion – Israel Institute of Technology · IL

Funding

PUBLIC HEALTH DEMONSTRATIONP60DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1985 to 2012
$26.5M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3M
The Role of PPAR-gamma in Vascular Lesion FormationR01HL068878 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2002 to 2019
$7.6M
The Role of TM6SF2 in Cardiovascular DiseaseR01HL137214 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2017 to 2020
$2.2M
Transcription Factor-EB and Postischemic AngiogenesisR01HL138094 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAN, YANBO · 2017 to 2021
$2.2M
Conjugated linoleic acid nitration in vascular inflammation and atherosclerosisR01HL123333 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VILLACORTA, LUIS · 2015 to 2019
$2.0M
In vivo photoacoustic biopsy for intestinal strictures in Crohn's diseaseR21AI122098 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HIGGINS, PETER D.R., XU, GUAN · 2016 to 2017
$397k
NHLBI NIH HHS R01 HL068878NHLBI NIH HHS R01 HL123333NHLBI NIH HHS R01 HL137214NHLBI NIH HHS R01 HL138094NIAID NIH HHS R21 AI122098NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS P60 DK020572
6 · The paper itself

Abstract

backgroundNonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are reaching global epidemic proportions. Lack of non-invasive diagnostic tools and effective therapies constitute two of the major hurdles for a bona fide treatment and a reversal of NASH progression and/or regression of the disease. Nitro-oleic acid (OA-NO

methodsNon-invasive imaging (e.g. photoacustic-ultrasound (PA-US)) was pursued to establish advanced experimental model of NASH in mice in which both steatosis and fibrosis were diagnosed prior experimental therapy with OA-NO

findingsCLAMS and NMR-based analysis demonstrates that OA-NO

interpretationOA-NO

Indexed as

AnimalsEnergy MetabolismLipogenesisLiverMaleMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseOleic AcidsProteolysisSterol Regulatory Element Binding Protein 1Triglycerides10-nitro-oleic acidOleic AcidsSrebf1 protein, mouseSterol Regulatory Element Binding Protein 1TriglyceridesNitro-fatty acidsNon-alcoholic fatty liver diseaseNon-alcoholic SteatohepatitisNon-invasive liver imaging, liver fibrosis

Identifiers

PMID30772307
PMCPMC6444056
OpenAlexW2914978609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.