ArticleParkinsonism & related disorders2019
Altered functional network topology correlates with clinical measures in very early-stage, drug-naïve Parkinson's disease.
Article in Parkinsonism & related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Analyzing Information Exchange in Parkinson's Disease via Eigenvector Centrality: A Source-Level Magnetoencephalography Study.Journal of clinical medicine · 2025Article
- Functional Brain Network Disruptions in Parkinson's Disease: Insights from Information Theory and Machine Learning.Diagnostics (Basel, Switzerland) · 2024Article
- Disrupted Brain Network Measures in Parkinson's Disease Patients with Severe Hyposmia and Cognitively Normal Ability.Brain sciences · 2024Article
- Topological disruption of high-order functional networks in cognitively preserved Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- The evolution of Big Data in neuroscience and neurology.Journal of big data · 2023Article
- Brain functional network abnormalities in parkinson's disease with mild cognitive impairment.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Directed Brain Connectivity Identifies Widespread Functional Network Abnormalities in Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Effect of deep brain stimulation on brain network and white matter integrity in Parkinson's disease.CNS neuroscience & therapeutics · 2022Article
- Comparative Study on Topological Properties of the Whole-Brain Functional Connectome in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease Without RBD.Frontiers in aging neuroscience · 2022Article
- Unique white matter structural connectivity in early-stage drug-naive Parkinson disease.Neurology · 2020Article
- Translation Imaging in Parkinson's Disease: Focus on Neuroinflammation.Frontiers in aging neuroscience · 2020Article
- Graph theory analysis of resting-state functional magnetic resonance imaging in essential tremor.Human brain mapping · 2019Article
- Structural Imaging in Parkinson's Disease: New Developments.Current neurology and neuroscience reports · 2019Review
- Topological reorganization of functional hubs in patients with Parkinson's disease with freezing of gait.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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7 authors.
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Abstract
introductionThe aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients.
methodsFunctional-MRI data for 16 healthy controls and 20 very early-stage, drug-naïve patients with PD were obtained from the Parkinson's Progression Markers Initiative database after controlling for strict inclusion/exclusion imaging criteria. Connectivity between regions of interest was estimated using Pearson's correlation between averaged time-series, and subsequently a connectivity matrix was obtained for each subject. These connectivity matrices were then used in an unbiased, whole-brain graph theoretical approach to investigate the functional connectome and its correlation with disease severity in very early PD.
resultsThe current study revealed altered network topology which correlated with multiple clinical measures in very early drug-naïve PD. Decreased functional segregation and integration (both globally and locally) were evident in PD. Importantly, our results demonstrated that most of the cortical regions hypothesized to be involved early in PD manifested decreased graph theoretical measures, despite utilizing a whole-brain analytic approach that is free from prior assumptions regarding cortical region involvement.
conclusionGraph theoretical investigation of very early drug-naïve PD revealed disrupted topological organization. These findings are evident in a stringently homogeneous group of very early-stage, medication-naive, and non-tremor dominant PD patients by using a whole-brain unbiased approach. These results provide an important unbiased and rigorously controlled baseline for understanding further studies of PD functional connectivity investigating response to treatment, symptom development, and disease progression.
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