Evidence map›Paper›PMID 30772168›Full record

ArticleNuclear medicine and biology2019

Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction.

Zhonglin Liu, Christy Barber, Akash Gupta, Li Wan, Young-Wook Won, Lars R Furenlid, Qin Chen, Ankit A Desai, Ming Zhao, David A Bull and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nuclear medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Recent advances in micro-sized oxygen carriers inspired by red blood cells.Science and technology of advanced materials · 2023
    Review
  2. Review
  3. Radionuclide imaging of apoptosis for clinical application.European journal of nuclear medicine and molecular imaging · 2022
    Review
  4. Development of Ultrasound Microbubbles and Phase Shift Microbubbles in Theranostics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zhonglin LiuDepartment of Medical Imaging, University of Arizona, Tucson, AZ, United States of America. Electronic address: zliu@email.arizona.edu.
Christy BarberDepartment of Medical Imaging, University of Arizona, Tucson, AZ, United States of America.
Akash GuptaDivision of Cardiology of Department of Medicine, University of Arizona, Tucson, AZ, United States of America.
Li WanDepartment of Medical Imaging, University of Arizona, Tucson, AZ, United States of America.
Young-Wook WonDivision of Cardiothoracic Surgery of Department of Surgery, University of Arizona, Tucson, AZ, United States of America.
Lars R FurenlidDepartment of Medical Imaging, University of Arizona, Tucson, AZ, United States of America.
Qin ChenDepartment of Pharmacology, University of Arizona, Tucson, AZ, United States of America.
Ankit A DesaiDivision of Cardiology of Department of Medicine, University of Arizona, Tucson, AZ, United States of America.
Ming ZhaoFeinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
David A BullDivision of Cardiothoracic Surgery of Department of Surgery, University of Arizona, Tucson, AZ, United States of America.
Evan C UngerDepartment of Medical Imaging, University of Arizona, Tucson, AZ, United States of America; NuvOx Pharma, LLC., Tucson, AZ, United States of America.
Diego R MartinDepartment of Medical Imaging, University of Arizona, Tucson, AZ, United States of America. Electronic address: dmartin@radiology.arizona.edu.
University of Arizona · USBanner - University Medical Center Tucson · USNorthwestern University · US

Funding

CENTER FOR GAMMA RAY IMAGINGP41EB002035 · NIBIB · UNIVERSITY OF ARIZONA · PI BARRETT, HARRISON H, FURENLID, LARS R · 2003 to 2018
$17.7M
Pathogenic Role of IL-18 in Sickle Cell Cardiomyopathy and Inducible Ventricular TachycardiaR01HL136603 · NHLBI · UNIVERSITY OF ARIZONA · PI DESAI, ANKIT A · 2017 to 2021
$2.4M
Targeted Systemic Delivery of SDF-1 DNA for the Treatment of Chronic Heart DiseaseR01HL138242 · NHLBI · UNIVERSITY OF NORTH TEXAS · PI WON, YOUNG-WOOK · 2017 to 2021
$2.3M
(PQD5) imaging systemic tissue injuries induced by anticancer drugsR01CA185214 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI O'HALLORAN, THOMAS V, ZHAO, MING · 2014 to 2017
$2.0M
Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic HeartsR01HL090716 · NHLBI · UNIVERSITY OF ARIZONA · PI LIU, ZHONGLIN · 2009 to 2012
$1.5M
NCI NIH HHS R01 CA185214NHLBI NIH HHS R01 HL090716NHLBI NIH HHS R01 HL136603NHLBI NIH HHS R01 HL138242NIBIB NIH HHS P41 EB002035
6 · The paper itself

Abstract

introductionThe objective of this study was to investigate the cardioprotective effects of a dodecafluoropentane (DDFP)-based perfluorocarbon emulsion (DDFPe) as an artificial carrier for oxygen delivery to ischemic myocardium, using

methodsRat hearts with Ischemia-reperfusion (I/R) was prepared by coronary ligation for 45-min followed by reperfusion. The feasibility of

resultsSPECT images, showing "hot-spot"

conclusionsSignificant reduction in myocardial I/R injury, as assessed by

Indexed as

Tomography, Emission-Computed, Single-PhotonAnimalsBacteriocinsCardiotonic AgentsFluorocarbonsHumansKineticsMyocardial InfarctionMyocardiumOrganotechnetium CompoundsOxygenPentanesRatsRats, Sprague-DawleyBacteriocinsCardiotonic AgentsFluorocarbonsOrganotechnetium CompoundsOxygenPentanesperfluoropentanetechnetium 99m HYNIC-duramycin(99m)Tc-DuramycinCell death imagingDodecafluoropentane perfluorocarbon emulsionMyocardial ischemia-reperfusionPhosphatidylethanolamine

Identifiers

PMID30772168
PMCPMC6778684
OpenAlexW2909087283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.