ArticleEnvironmental pollution (Barking, Essex : 1987)2019
Changes in blood pressure associated with lead, manganese, and selenium in a Bangladeshi cohort.
Article in Environmental pollution (Barking, Essex : 1987), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Selenite Interacting with Thiols Catalytically Releases NO from GSNO, Cleaves Plasmid DNA and Reduces the Hypotensive Effect of GSNO in Rats.Biological trace element research · 2026Article
- The Association of Arsenic Metabolism and Blood Pressure: A Cross-Sectional Analysis in the MesoAmerican Nephropathy Occupational Study (MANOS).Research square · 2026Article
- Metal Mixtures Mediate the Socioeconomic Gradient in Blood Pressure: A Four-Way Decomposition in a Prospective Rural Bangladeshi Cohort.medRxiv : the preprint server for health sciences · 2025Article
- Exposure to Multiple Metal(loid)s and Hypertension in Chinese Older Adults.Biological trace element research · 2025Article
- The Impact of Blood Lead and Its Interaction with Occupational Factors and Air Pollution on Hypertension Prevalence.Toxics · 2024Article
- A cross-sectional analysis of the PURE study on minerals intake among Malaysian adult population with hypertension.Scientific reports · 2024Article
- Associations between patterns of blood heavy metal exposure and health outcomes: insights from NHANES 2011-2016.BMC public health · 2024Article
- Individual, Independent, and Joint Associations of Toxic Metals and Manganese on Hypertensive Disorders of Pregnancy: Results from the MIREC Canadian Pregnancy Cohort.Environmental health perspectives · 2023Article
- Scientific opinion on the tolerable upper intake level for selenium.EFSA journal. European Food Safety Authority · 2023Article
- Validation of blood arsenic and manganese assessment from archived clotted erythrocyte fraction in an urban cohort of mother-child dyads.The Science of the total environment · 2022Article
- Family History of Hypertension and Cobalt Exposure Synergistically Promote the Prevalence of Hypertension.Biological trace element research · 2022Article
- Exposure to Metal Mixtures in Association with Cardiovascular Risk Factors and Outcomes: A Scoping Review.Toxics · 2022Article
- Novel Strategies for Assessing Associations Between Selenium Biomarkers and Cardiometabolic Risk Factors: Concentration, Visit-to-Visit Variability, or Individual Mean? Evidence From a Repeated-Measures Study of Older Adults With High Selenium.Frontiers in nutrition · 2022Article
- The association between blood metals and hypertension in the GuLF study.Environmental research · 2021Article
- Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries.Environmental health and preventive medicine · 2021Article
- Blood Lead, Systemic Inflammation, and Blood Pressure: Exploring Associations and Mediation Effects in Workers Exposed to Lead.Biological trace element research · 2021Article
- Article
- Invited Perspective: Metal Mixtures and Child Health: The Complex Interplay of Essential and Toxic Elements.Environmental health perspectives · 2021Article
- Exposure to metal mixtures in relation to blood pressure among children 5-7 years old: An observational study in Bangladesh.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- A Nonlinear Relation Between Maternal Red Blood Cell Manganese Concentrations and Child Blood Pressure at Age 6-12 y: A Prospective Birth Cohort Study.The Journal of nutrition · 2021Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundHeavy metal contamination is widespread in Bangladesh. Previous studies have observed lead increases blood pressure over time. However, the role of other metal contaminants and essential micronutrients, which could also adversely affect blood pressure or act as protective factors, is understudied.
objectivesWe therefore evaluated the associations of lead, manganese, and selenium with blood and pulse pressure trajectories.
methodsWe prospectively followed placebo-assigned participants nested within a randomized trial for the prevention of arsenic-related skin cancer (n = 255). Blood lead, manganese, and selenium were measured at baseline; blood pressure was measured at baseline and at 3 biennial follow-up examinations. Mixed-effect linear regression models were used to estimate associations with average annual changes in systolic, diastolic, and pulse pressure.
resultsIn models simultaneously adjusted for baseline blood lead, manganese, and selenium concentrations in addition to other potential confounders, lead was linearly associated with increases in systolic blood pressure, but not with diastolic blood pressure or pulse pressure. A non-linear association was observed for manganese, such that mid-range concentrations were associated with decreases in systolic, diastolic, and pulse pressure. Baseline selenium concentrations in the highest quartile were also associated with longitudinal decreases in both systolic and diastolic blood pressure, while null associations were observed with pulse pressure. In exploratory analyses, the combination of mid-range manganese and high selenium concentrations completely offset lead-associated increases in blood and pulse pressure.
conclusionsThe results indicate a direct, linear association of lead exposure with systolic blood pressure, and manganese and selenium exposures within certain ranges may have a blood pressure-lowering effect in this population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.