Evidence map›Paper›PMID 30771726›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2019

Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.

Eleonora Tamilia, Michel AlHilani, Naoaki Tanaka, Melissa Tsuboyama, Jurriaan M Peters, P Ellen Grant, Joseph R Madsen, Steven M Stufflebeam, Phillip L Pearl, Christos Papadelis

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
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  4. Combining interictal and ictal low-density EEG source imaging to delineate the epileptogenic zone in young children.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  5. Mapping epileptogenic brain using a unified spatial-temporal-spectral source imaging framework.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  12. Review
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  15. Review
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  17. Magnetoencephalography for Epilepsy Presurgical Evaluation.Current neurology and neuroscience reports · 2024
    Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eleonora TamiliaLaboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Michel AlHilaniLaboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Naoaki TanakaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Sapporo Neuroimaging Research Group, Sapporo, Japan.
Melissa TsuboyamaDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jurriaan M PetersDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
P Ellen GrantFetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Joseph R MadsenDivision of Epilepsy Surgery, Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, USA.
Steven M StufflebeamAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Phillip L PearlDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Christos PapadelisLaboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: christos.papadelis@childrens.harvard.edu.

Funding

Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
Interictal High Frequency Oscillations of Epileptogenecity in Pediatric PatientsR01NS104116 · NINDS · COOK CHILDREN'S MEDICAL CENTER · PI PAPADELIS, CHRISTOS · 2019 to 2024
$2.4M
Interictal High Frequency Oscillations of Epileptogenecity in Pediatric PatientsR21NS101373 · NINDS · COOK CHILDREN'S MEDICAL CENTER · PI PAPADELIS, CHRISTOS, STUFFLEBEAM, STEVEN · 2018 to 2019
$501k
NICHD NIH HHS U54 HD090255NINDS NIH HHS R01 NS104116NINDS NIH HHS R21 NS101373
6 · The paper itself

Abstract

objectiveTo evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

methodsTwenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). We compared the localization error (E

resultsMEG presented lower E

conclusionsMEG localizes the IZ more accurately than conv-EEG and HD-EEG. MSI may help the presurgical evaluation in terms of patient's outcome prediction. The promising clinical value of ESI for both conv-EEG and HD-EEG prompts the use of higher-density EEG-systems to possibly achieve MEG performance. SIGNIFICANCE: Localizing the IZ non-invasively with MSI/ESI facilitates presurgical evaluation and surgical prognosis assessment.

Indexed as

AdolescentCerebral CortexChildChild, PreschoolCortical ExcitabilityElectroencephalographyEpilepsyFemaleHumansInfantMagnetic Resonance ImagingMagnetoencephalographyMaleReproducibility of ResultsEEGEpilepsy surgeryIntracranial EEGIrritative zoneMagnetoencephalographySource localization

Identifiers

PMID30771726
PMCPMC8903800

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.