ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2019
Differences between flexion and extension synergy-driven coupling at the elbow, wrist, and fingers of individuals with chronic hemiparetic stroke.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Quantifying Quality of Reaching Movements Longitudinally Post-Stroke: A Systematic Review.Neurorehabilitation and neural repair · 2022Pooled it
- Three-dimensional assessment of finger individuation reveals finger- and joint-specific selective motor control deficits in children with cerebral palsy.Journal of neuroengineering and rehabilitation · 2026Trial
- Novel Compact Tactile Stimulator with Sensing: Designed for Individuals with a Brain Injury and MRI.IEEE transactions on medical robotics and bionics · 2026Article
- Self-Organizing Recruitment of Compensatory Cortical Areas Post-Stroke Can Maximize Residual Motor Performance.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Corticomuscular coupling study for post-stroke rehabilitation: a scoping review.Journal of neuroengineering and rehabilitation · 2025Article
- Generalizability of neuromuscular coordination in the human upper extremity after stroke and its implications in neurorehabilitation.Journal of neuroengineering and rehabilitation · 2025Article
- Pathophysiology of voluntary motor commands at the level of the spinal motoneuron in patients with multiple sclerosis.medRxiv : the preprint server for health sciences · 2025Article
- Three-dimensional assessment of finger individuation reveals finger- and joint-specific selective motor control deficits in pediatric cerebral palsy.Research square · 2025Article
- Correlation analysis of upper limb muscle activation in the frequency domain in wheelchair fencers.Frontiers in human neuroscience · 2025Article
- Human-in-the-Loop Myoelectric Pattern Recognition Control of an Arm-Support Robot to Improve Reaching in Stroke Survivors.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025Article
- Alterations of upper-extremity functional muscle networks in chronic stroke survivors.Experimental brain research · 2024Article
- Volitional Control of the Paretic Hand Post-Stroke Increases Finger Stiffness and Resistance to Robot-Assisted Movement.Proceedings of the ... IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics. IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics · 2024Article
- Evolution, biomechanics, and neurobiology converge to explain selective finger motor control.Physiological reviews · 2024Review
- Moving toward elucidating alternative motor pathway structures post-stroke: the value of spinal cord neuroimaging.Frontiers in neurology · 2024Review
- Individuals with hemiparetic stroke abnormally perceive their elbow torques when abducting their paretic shoulder.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Motor unit firing rate modulation is more impaired during flexion synergy-driven contractions of the biceps brachii in chronic stroke.medRxiv : the preprint server for health sciences · 2023Article
- MCP extensors respond faster than flexors in individuals with severe-to-moderate stroke-caused impairment: Evidence of uncoupled neural pathways.Frontiers in neurology · 2023Article
- Abnormal proximal-distal interactions in upper-limb of stroke survivors during object manipulation: A pilot study.Frontiers in human neuroscience · 2022Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveThe flexion and extension synergies were quantified at the paretic elbow, forearm, wrist, and finger joints within the same group of participants for the first time. Differences in synergy expression at each of the four joints were examined, as were the ways these differences varied across the joints.
methodsTwelve post-stroke individuals with chronic moderate-to-severe hemiparesis and six age-matched controls participated. Participants generated isometric shoulder abduction (SABD) and shoulder adduction (SADD) at four submaximal levels to progressively elicit the flexion and extension synergies, respectively. Isometric joint torques and EMG were recorded from shoulder, elbow, forearm (radio-ulnar), wrist, and finger joints and muscles.
resultsSABD elicited strong wrist and finger flexion torque that increased with shoulder torque level. SADD produced primarily wrist and finger flexion torque, but magnitudes at the wrist were less than during SABD. Findings contrasted with those at the elbow and forearm, where torques and EMG generated due to SABD and SADD were opposite in direction.
conclusionsFlexion and extension synergy expression are more similar at the hand than at the shoulder and elbow. Specific bulbospinal pathways that may underlie flexion and extension synergy expression are discussed. SIGNIFICANCE: Whole-limb behavior must be considered when examining paretic hand function in moderately-to-severely impaired individuals.
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