Evidence map›Paper›PMID 30771445›Full record

ArticleMagnetic resonance imaging2019

Evaluation of the sensitivity of R

Syed O Ali, Petros Fessas, Joshua D Kaggie, Fulvio Zaccagna, Gavin Houston, Scott Reid, Martin J Graves, Ferdia A Gallagher

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. TNMR in biomedicine · 2026
    Article
  2. Article
  3. Magnetic resonance myocardial T1ρ mapping : Technical overview, challenges, emerging developments, and clinical applications.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Syed O AliUniversity of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0SP, United Kingdom.
Petros FessasUniversity of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0SP, United Kingdom.
Joshua D KaggieDepartment of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ. Electronic address: jk636@cam.ac.uk.
Fulvio ZaccagnaDepartment of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ.
Gavin HoustonGE Healthcare, Amersham, United Kingdom, HP7 9JQ.
Scott ReidGE Healthcare, Amersham, United Kingdom, HP7 9JQ.
Martin J GravesDepartment of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ.
Ferdia A GallagherDepartment of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ. Electronic address: fag1000@cam.ac.uk.
University of Cambridge · GBAmersham Hospital · GB

Funding

Cancer Research UK 16465Cancer Research UK 16628Cancer Research UK C19212/A27150Cancer Research UK C19212/A29082Cancer Research UK C197/A16465Department of Health
6 · The paper itself

Abstract

The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has been used as a possible biomarker of salvageable tissue in ischemic stroke. A non-invasive MRI-based approach for the determination and imaging of cerebral pH would be a powerful tool in cancer diagnosis and monitoring, as well as stroke treatment planning. Several pH-based MRI imaging approaches have been proposed but for these to be useful, disentangling the effects of pH from other parameters which may affect the measured MRI signal is crucial to ensure accuracy and specificity. R

Indexed as

Hydrogen-Ion ConcentrationMagnetic Resonance ImagingPhantoms, ImagingBasal GangliaBrainBrain IschemiaBrain MappingContrast MediaGadoliniumGray MatterHealthy VolunteersHumansMacromolecular SubstancesMaleNeoplasm MetastasisNeoplasmsContrast MediaGadoliniumMacromolecular SubstancesMRIpHR(1)ρT(1)ρTumor microenvironment

Identifiers

PMID30771445
PMCPMC6422633
OpenAlexW2913202436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.