ArticleArthritis & rheumatology (Hoboken, N.J.)2019
Development and Validation of an
Article in Arthritis & rheumatology (Hoboken, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The EANM guideline for radiosynoviorthesis.European journal of nuclear medicine and molecular imaging · 2022Guideline
- Beyond Conventional Imaging: Nuclear Imaging in Rheumatoid Arthritis.Journal of clinical medicine · 2025Review
- Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT.Skeletal radiology · 2025Review
- Role of Positron Emission Tomography (PET) in the Diagnosis of Musculoskeletal Disorders.Journal of clinical medicine · 2025Review
- Role of PET/CT in diagnosing and monitoring disease activity in rheumatoid arthritis: a review.Annals of nuclear medicine · 2024Review
- A radioactive and fluorescent dual modality cysteine cathepsin-B activity-based probe for the detection and treatment evaluation in rheumatoid arthritis.American journal of nuclear medicine and molecular imaging · 2024Article
- Clinical features of atlantoaxial involvement in patients with rheumatoid arthritis usingClinical rheumatology · 2023Article
- ArticularThe Journal of rheumatology · 2022Article
- Total-BodyJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Observational
- 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography-computed tomography in rheumatological diseases.Rheumatology (Oxford, England) · 2022Review
- Early prediction of treatment response in rheumatoid arthritis by quantitative macrophage PET.RMD open · 2022Article
- Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis.Scientific reports · 2021Article
- Dissociation between 2-[BMC rheumatology · 2021Article
- Clinical utility of F-18 sodium fluoride PET/CT for estimating disease activity in patients with rheumatoid arthritis.Quantitative imaging in medicine and surgery · 2021Article
- Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?Arthritis research & therapy · 2021Article
- Clinical Use of Quantitative Analysis of Bone Scintigraphy to Assess the Involvement of Arthritis Diseases in Patients with Joint Symptoms.Diagnostics (Basel, Switzerland) · 2020Article
- Hepatic alveolar echinococcosis: correlation between computed tomography morphology and inflammatory activity in positron emission tomography.Scientific reports · 2020Article
- Evolving Use of Molecular Imaging in Research and in Practice.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Can Metabolic Pathways Be Therapeutic Targets in Rheumatoid Arthritis?Journal of clinical medicine · 2019Review
- A Case of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging of Eosinophilic Granulomatosis With Polyangiitis Combined With Non-tuberculous Mycobacterium.European journal of case reports in internal medicine · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
objectiveClinical joint count assessment is important for detecting synovitis but its reliability is a subject of controversy. This study was undertaken to assess the correlation of positron emission tomography (PET)-derived parameters in 68 joints with disease activity and to compare the reliability of joint counts between PET with computed tomography (CT) and clinical assessment in patients with rheumatoid arthritis (RA).
methodsWe enrolled 91 patients with active RA (69 in a development group and 22 in a validation group) who underwent concurrent
resultsThe number of PET-positive joints (of 28 and 68 joints) was significantly correlated with the swollen joint count (SJC) and tender joint count (TJC) and the DAS in 28 joints using the erythrocyte sedimentation rate (DAS28-ESR). Intraobserver and interobserver reliability of PET for the affected joint counts were excellent. Interobserver reliability between nuclear medicine physicians and rheumatologists was good for the SJC and TJC in both 28 joints and 68 joints. After multivariate analyses, including ESR and patient's global assessment of disease activity (PtGA) in addition to PET-derived parameters, the PET/DAS was derived as (0.063 × number of PET-positive joints in 28 joints) + (0.011 × ESR) + (0.030 × PtGA). A significant correlation between the PET/DAS and the DAS28-ESR was confirmed in the validation group (P < 0.001).
conclusionPET-CT could serve as a sensitive and reliable method in the evaluation of disease activity in RA patients, and may be applicable as a research tool, particularly in clinical trials.
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