Evidence map›Paper›PMID 30771223›Full record

ArticleThe Journal of physiology2020

PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.

Shanna Hamilton, Iuliia Polina, Radmila Terentyeva, Peter Bronk, Tae Yun Kim, Karim Roder, Richard T Clements, Gideon Koren, Bum-Rak Choi, Dmitry Terentyev

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Small-conductance CaThe Journal of physiology · 2026
    Review
  2. Restoration of mitochondrial CaJournal of molecular and cellular cardiology · 2026
    Article
  3. Review
  4. Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025
    Review
  5. Increased Intermembrane Space [CaCirculation research · 2025
    Article
  6. Article
  7. Activation of Small Conductance CaInternational journal of molecular sciences · 2025
    Article
  8. Activation of small conductance CaThe Journal of physiology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous CaAmerican journal of physiology. Heart and circulatory physiology · 2021
    Article
  15. Review
  16. Review
  17. Article
  18. The transient outward potassium current plays a key role in spiral wave breakup in ventricular tissue.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  19. Inhibition of Small-Conductance, CaFrontiers in pharmacology · 2021
    Article
  20. Small Conductance CaFrontiers in physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shanna HamiltonDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Iuliia PolinaDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Radmila TerentyevaDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Peter BronkDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Tae Yun KimDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Karim RoderDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Richard T ClementsDepartment of Surgery, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Gideon KorenDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Bum-Rak ChoiDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.
Dmitry TerentyevDepartment of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.ORCID 0000-0002-9530-7384
Brown University · USMedical University of South Carolina · US

Funding

A Multi-Scale Approach to Cardiac Arrhythmia: from the Molecule to the OrganR01HL110791 · NHLBI · RHODE ISLAND HOSPITAL · PI KOREN, GIDEON · 2013 to 2017
$7.3M
Novel Mechanisms of Regulation of SK channels: Implications for Cardiac ArrhythmiaR01HL142588 · NHLBI · OHIO STATE UNIVERSITY · PI TERENTYEV, DMITRY A · 2019 to 2022
$2.4M
REgulation of Calcium Homeostasis by MyomiRs in Heart FailureR01HL121796 · NHLBI · RHODE ISLAND HOSPITAL · PI TERENTYEV, DMITRY A · 2015 to 2019
$2.0M
Surgical Cardioprotection Through BKCa-Dependent Modulation of Mitochondrial SupercomplexesR01HL135236 · NHLBI · UNIVERSITY OF RHODE ISLAND · PI CLEMENTS, RICHARD T · 2018 to 2021
$1.9M
The role of dynamic changes in repolarization and calcium transients in Long QT rR01HL096669 · NHLBI · RHODE ISLAND HOSPITAL · PI CHOI, BUM-RAK · 2009 to 2013
$1.9M
American Heart Association 18POST33960456American Heart Association Aid 15GRNT25650002NHLBI NIH HHS R01 HL096669NHLBI NIH HHS R01HL096669NHLBI NIH HHS R01 HL110791NHLBI NIH HHS R01HL110791NHLBI NIH HHS R01 HL121796NHLBI NIH HHS R01HL121796NHLBI NIH HHS R01 HL135236NHLBI NIH HHS R01 HL142588NHLBI NIH HHS RO1HL135236
6 · The paper itself

Abstract

key pointsSmall-conductance Ca ABSTRACT: Small-conductance Ca

Indexed as

Myocytes, CardiacSmall-Conductance Calcium-Activated Potassium ChannelsAnimalsApaminCardiomegalyPhosphorylationRatsApaminSmall-Conductance Calcium-Activated Potassium ChannelsCalcium transientsCardiac electrophysiologyPKASmall-conductance Ca2+-activated K+ channelsVentricular arrhythmia

Identifiers

PMID30771223
PMCPMC7496687
OpenAlexW2914762618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.