Evidence map›Paper›PMID 30770883›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury.

Noelia González-Pacheco, Manuel Sánchez-Luna, Paz Chimenti-Camacho, Martín Santos-González, Paula Palau-Concejo, Francisco Tendillo-Cortijo

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  8. Review
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  12. Review
  13. [Prospects and developments in the technologies of high frequency oscillatory ventilation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021
    Article
  14. Article
  15. Observational
  16. DCOEuropean journal of pediatrics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Noelia González-PachecoNeonatology Department, Hospital Universitario Gregorio Marañón, Biomedical Research Institute Gregorio Marañón, Complutense University of Madrid, Madrid, Spain.
Manuel Sánchez-LunaNeonatology Department, Hospital Universitario Gregorio Marañón, Biomedical Research Institute Gregorio Marañón, Complutense University of Madrid, Madrid, Spain. msluna@salud.madrid.org.
Paz Chimenti-CamachoNeonatology Department, Hospital Universitario Gregorio Marañón, Biomedical Research Institute Gregorio Marañón, Complutense University of Madrid, Madrid, Spain.
Martín Santos-GonzálezMedical and Surgical Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
Paula Palau-ConcejoServicio de Inmunología, Laboratorio de Inmuno-Biología Molecular, Hospital Universitario Gregorio Marañón, Madrid, Spain.
Francisco Tendillo-CortijoMedical and Surgical Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
Hospital General Universitario Gregorio Marañón · ESHospital Universitario Puerta de Hierro Majadahonda · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO

objectiveTo demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model. STUDY

designExperimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO

resultsWe found in the 10 Hz group with the higher VThf compared with the 20 Hz and very low VThf group more evident and more severe histological lesions with inflammatory infiltrate within the alveolar wall and alveolar space, as well as large areas of parenchyma consolidation and areas of alveolar hemorrhage in the more severe cases.

conclusionThe use of very low VThf compared with higher VThf at similar CO

Indexed as

Tidal VolumeAnimalsAnimals, NewbornDisease Models, AnimalHigh-Frequency VentilationHumansInfant, NewbornRespiratory Distress Syndrome, NewbornSwineVentilator-Induced Lung Injury

Identifiers

PMID30770883
OpenAlexW2912335210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.