ArticleScientific reports2019
Honey bees long-lasting locomotor deficits after exposure to the diamide chlorantraniliprole are accompanied by brain and muscular calcium channels alterations.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Acute Exposure to Traces of Chlorantraniliprole Does Not Alter Antipredator Behaviour in Wild Crickets.Ecology and evolution · 2026Article
- Acute Toxicity and Locomotor Effects of Oral Exposure to the Insecticide Indoxacarb in Two Species of Neotropical Stingless Bees, Melipona beecheii and Nannotrigona perilampoides.Neotropical entomology · 2026Article
- Intracellular calcium handling dysfunction contributes to behavioural deficits leading to mortality of honey bees after acute contact exposure to the insecticide cyantraniliprole.Scientific reports · 2026Article
- Nanopesticides in Brazilian Crops: Classes, Mechanisms, Efficacy, Risks, and Photocatalytic Remediation.Plants (Basel, Switzerland) · 2025Review
- Computational new approach methods guide focused testing and enhance understanding of chlorantraniliprole toxicity across species.Environmental toxicology and chemistry · 2025Article
- Changes in the proteome of Apis mellifera acutely exposed to sublethal dosage of glyphosate and imidacloprid.Environmental science and pollution research international · 2024Article
- Cardiotoxicity of the diamide insecticide chlorantraniliprole in the intact heart and in isolated cardiomyocytes from the honey bee.Scientific reports · 2024Article
- Successful application of anthranilic diamides in preventing small hive beetle (Coleoptera: Nitidulidae) infestation in honey bee (Hymenoptera: Apidae) colonies.Journal of insect science (Online) · 2023Article
- Survival Rate of the Neotropical Stingless BeesInsects · 2022Article
- A mechanism-based approach unveils metabolic routes potentially mediating chlorantraniliprole synergism in honey bees, Apis mellifera L., by azole fungicides.Pest management science · 2022Article
- Article
- Extraction and determination of flubendiamide insecticide in food samples: A review.Current research in food science · 2022Review
- Elementary calcium release events in the skeletal muscle cells of the honey bee Apis mellifera.Scientific reports · 2021Article
- Structural basis for diamide modulation of ryanodine receptor.Nature chemical biology · 2020Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diamides belong to one of the newest insecticides class. We characterized cellular effects of the first commercialized diamide, chlorantraniliprole (ChlorAnt). ChlorAnt not only induces a dose-dependent calcium release from internal stores of honey bee muscle cells, but also a dose-dependent blockade of the voltage-gated calcium current involved in muscles and brain excitability. We measured a long lasting impairment in locomotion after exposure to a sublethal dose and despite an apparent remission, bees suffer a critical relapse seven days later. A dose that was sublethal when applied onto the thorax turned out to induce severe mortality when applied on other body parts. Our results may help in filling the gap in the toxicological evaluation of insecticides that has recently been pointed out by international instances due to the lack of suitable tests to measure sublethal toxicity. Intoxication symptoms in bees with ChlorAnt are consistent with a mode of action on intracellular calcium release channels (ryanodine receptors, RyR) and plasma membrane voltage-gated calcium channels (Ca
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