Evidence map›Paper›PMID 30770821›Full record

ArticleNature communications2019

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence.

Mariya I Goncheva, Ronald S Flannagan, Brigid E Sterling, Holly A Laakso, Nancy C Friedrich, Julienne C Kaiser, David W Watson, Christy H Wilson, Jessica R Sheldon, Martin J McGavin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
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  6. Calcium regulation ofApplied and environmental microbiology · 2026
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  12. The dynamic interplay betweenFrontiers in cellular and infection microbiology · 2026
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  17. UnravelingmSystems · 2025
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  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Mariya I GonchevaDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.ORCID http://orcid.org/0000-0001-9796-6060
Ronald S FlannaganDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.ORCID http://orcid.org/0000-0002-3263-2227
Brigid E SterlingDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.
Holly A LaaksoDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.
Nancy C FriedrichDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.
Julienne C KaiserDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.
David W WatsonDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.
Christy H WilsonDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.
Jessica R SheldonDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.
Martin J McGavinDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1.
Patti K KiserDepartment of Pathology, University of Western Ontario, London, ON, Canada, N6A 5C1.
David E HeinrichsDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, N6A 5C1. deh@uwo.ca.ORCID http://orcid.org/0000-0002-7217-2456
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus. Indeed, systemic infection with purR mutants causes accelerated mortality in mice, which is due to aberrant up-regulation of fibronectin binding proteins (FnBPs). Remarkably, purR mutations can arise upon exposure of S. aureus to stress, such as an intact immune system. In humans, naturally occurring anti-FnBP antibodies exist that, while not protective against recurrent S. aureus infection, ostensibly protect against hypervirulent S. aureus infections. Vaccination studies support this notion, where anti-Fnb antibodies in mice protect against purR hypervirulence. These findings provide a novel link between purine metabolism and virulence in S. aureus.

Indexed as

AnimalsCarrier ProteinsFemaleFibronectinsMaleMiceMice, Inbred BALB CMutationProtein BindingPurinesStaphylococcus aureusVirulenceCarrier ProteinsFibronectinspurinePurines

Identifiers

PMID30770821
PMCPMC6377658
OpenAlexW2914290436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.