Observational studyWorld journal of surgical oncology2019
Repeat hepatectomy with systemic chemotherapy might improve survival of recurrent liver metastasis from colorectal cancer-a retrospective observational study.
Observational study in World journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Updated insights into the impact of adjuvant chemotherapy on recurrence and survival after curative resection of liver or lung metastases in colorectal cancer: a rapid review and meta-analysis.World journal of surgical oncology · 2025Pooled it
- Complete Resection of Simultaneous Hepatic and Pulmonary Metastases from Colorectal Cancer in the Era of Modern Systemic and Surgical Therapies: A Systematic Review and Meta-Analysis.Annals of surgical oncology · 2026Review
- Comparison of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced MRI and contrast-enhanced CT evaluation of liver tumors: a prospective study.Abdominal radiology (New York) · 2026Article
- Iterative Hepatic and Pulmonary Metastasectomy in Stage IV Colorectal Cancer: Impact on Survival and Surgical Outcomes.Annals of surgical oncology · 2026Article
- POLE2 silencing inhibits the progression of colorectal carcinoma cells via wnt signaling axis.Cancer biology & therapy · 2024Article
- Predicting early extrahepatic recurrence after local treatment of colorectal liver metastases.The British journal of surgery · 2023Article
- Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells.Cancer & metabolism · 2023Article
- The neutrophil-to-lymphocyte ratio and lactate dehydrogenase combined in predicting liver metastasis and prognosis of colorectal cancer.Frontiers in medicine · 2023Article
- Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC).Journal of surgical oncology · 2022Article
- The pattern and treatment outcomes for rectal cancer with concurrent locoregional recurrence and distant metastases after total mesorectal excision.BMC cancer · 2022Article
- Comprehensive Genomic Profiling (CGP)-Informed Personalized Molecular Residual Disease (MRD) Detection: An Exploratory Analysis from the PREDATOR Study of Metastatic Colorectal Cancer (mCRC) Patients Undergoing Surgical Resection.International journal of molecular sciences · 2022Article
- Article
- Resection strategy for colorectal liver metastasis focusing on intrahepatic vessels and resection margins.Surgery today · 2021Article
- Colorectal Cancer, Liver Metastases and Biotherapies.Biomedicines · 2021Review
- AMIGO2 as a novel indicator of liver metastasis in patients with colorectal cancer.Oncology letters · 2021Article
- Recurrence After Liver Resection of Colorectal Liver Metastases: Repeat Resection or Ablation Followed by Hepatic Arterial Infusion Pump Chemotherapy.Annals of surgical oncology · 2021Article
- Review
- Current status of laparoscopic liver resection for the management of colorectal liver metastases.Journal of gastrointestinal oncology · 2020Review
- Oncological outcomes of repeat metastasectomy for recurrence after hepatectomy for colorectal liver metastases. A case series.Annals of medicine and surgery (2012) · 2020Article
- Emerging Role of Immunotherapy for Colorectal Cancer with Liver Metastasis.OncoTargets and therapy · 2020Review
Corrections and comments
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15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough hepatectomy for metastatic colorectal cancer (mCRC) prolongs survival in up to 40% of people, recurrence rates approach 70%. We used a multidisciplinary approach to treat recurrent liver metastases, including chemotherapy, surgery, and palliative care. On the other hand, development of chemotherapeutic agents is remarkable and improves long-term survival. However, whether chemotherapy and repeat hepatectomy combination therapy improve survival or not is still unclear. The aim of this study was to analyze the outcomes of repeat hepatectomy with systemic chemotherapy for mCRC.
methodsFollowing Institutional Review Board approval, we reviewed the records of all patients who underwent hepatectomy for mCRC between 1974 and 2015 at Fujita Health University Hospital. We used the Kaplan-Meier method to estimate overall survival from the first and last hepatectomy in multi hepatectomy cases after 2005 and compared outcomes between groups using the log-rank test.
resultsA total of 426 liver resections were performed for mCRC; of these, 236 cases were performed after 2005 (late group). In 118 (50%) cases, the site of recurrence was the liver, 59 (50%) underwent repeat hepatectomy, and 14 cases had ≥ 2 repeat hepatectomies. Overall survival (OS) before and after 2005 was 42.2 and 64.1 months, respectively, with the late group having better OS compared to the early (1974-2004) group. OS for single hepatectomy cases was 83.2 months, for two hepatectomies was 42.9 months, and for three hepatectomies was 35.3 months. In total, 59 patients did not undergo surgery after recurrence with an OS of 28.7 months. Mortality of the second and third repeat hepatectomy was 1.7% and 15.3%, respectively.
conclusionRepeat hepatectomy with systemic chemotherapy for mCRC is feasible and might achieve improved survival in carefully selected patients.
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