Evidence map›Paper›PMID 30770605›Full record

ArticleHead & neck2019

"Cold turkey" or pharmacotherapy: Examination of tobacco cessation methods tried among smokers prior to developing head and neck cancer.

Samir S Khariwala, Nathan Rubin, Irina Stepanov, Nicole Nollen, Jasjit S Ahluwalia, Heather H Nelson, Dorothy K Hatsukami

Abstract read
In one paragraph

Article in Head & neck, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Persistent Tobacco Use After Treatment for Head and Neck Cancer.JAMA otolaryngology-- head & neck surgery · 2022
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samir S KhariwalaDepartment of Otolaryngology - Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-5579-4990
Nathan RubinMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Irina StepanovMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Nicole NollenDepartment of Preventive Medicine and Public Health, University of Kansas, Kansas City, Kansas.
Jasjit S AhluwaliaDepartment of Behavioral and Social Sciences, Brown University School of Public Health, Providence.
Heather H NelsonMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Dorothy K HatsukamiMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Tobacco carcinogens as markers of exposure, carcinogenesis and risk in oral canceK23DE023572 · NIDCR · UNIVERSITY OF MINNESOTA · PI KHARIWALA, SAMIR S · 2013 to 2017
$681k
NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR002494NCI NIH HHS P30 CA077598NIDCR/NIH K23DE023572NIDCR NIH HHS K23 DE023572NIH HHS P30 CA77598
6 · The paper itself

Abstract

backgroundTobacco cessation methods employed by patients with head and neck cancer (HNSCC) are previously unstudied and have the potential to inform choice of cessation method and necessary abstinence support.

methodsA total of 130 current smokers with HNSCC were queried regarding prior unsuccessful tobacco cessation techniques, product used (cold turkey, varenicline, and nicotine patch/gum), and maximum time abstained from smoking.

resultsOne hundred six smokers retrospectively reported using one of the four main quit methods. Unassisted cessation ("cold turkey") was the most commonly used method (P < .001). A multiple ordinal logistic general estimating equation analysis revealed that cold turkey had increased odds [5.2 (95% confidence interval [CI]: 2.2, 11.8) and 4.3 (95% CI: 1.5, 12.9)] of achieving a longer quit duration than the nicotine patch or varenicline, respectively.

conclusionsAmong smokers developing HNSCC, previous cessation attempts were most commonly unassisted. This method was associated with longest abstinence periods. These data suggest insufficient support and education regarding behavioral and pharmacologic cessation therapies.

Indexed as

AdultAgedCarcinoma, Squamous CellCross-Sectional StudiesFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedRetrospective StudiesSmoking Cessation AgentsTime FactorsTobacco Use CessationTobacco Use Cessation DevicesVareniclineSmoking Cessation AgentsVareniclinecold turkeyhead and neck cancernicotinetobacco cessationvarenicline

Identifiers

PMID30770605
PMCPMC6579626

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.