Evidence map›Paper›PMID 30770479›Full record

ReviewJournal of cell science2019

The unfolded protein response in metazoan development.

Sahana Mitra, Hyung Don Ryoo

Abstract readReview
In one paragraph

Review in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sahana MitraDepartment of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
Hyung Don RyooDepartment of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA hyungdon.ryoo@nyumc.org.ORCID 0000-0002-1046-535X
New York University · US

Funding

Unfolded Protein Response in Eye Development and DiseaseR01EY020866 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HYUNG D RYOO · 2010 to 2026
$6.9M
Translation control of stress response and innate immunityR01GM125954 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RYOO, HYUNG D · 2018 to 2021
$1.4M
NEI NIH HHS R01 EY020866NIGMS NIH HHS R01 GM125954
6 · The paper itself

Abstract

Eukaryotic cells respond to an overload of unfolded proteins in the endoplasmic reticulum (ER) by activating signaling pathways that are referred to as the unfolded protein response (UPR). Much UPR research has been conducted in cultured cells that exhibit no baseline UPR activity until they are challenged by ER stress initiated by chemicals or mutant proteins. At the same time, many genes that mediate UPR signaling are essential for the development of organisms ranging from

Indexed as

Endoplasmic Reticulum StressUnfolded Protein ResponseAnimalsDrosophilaEndoplasmic ReticulumFishesGene Expression Regulation, DevelopmentalHumansOrgan SpecificitySignal TransductionATF4ATF6eIF2αEndoplasmic reticulumEyeIRE1PancreasPERKUnfolded protein responseXBP1

Identifiers

PMID30770479
PMCPMC6432711
OpenAlexW2913967176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.