Evidence map›Paper›PMID 30770473›Full record

ArticleThe Journal of biological chemistry2019

Development and structural characterization of an engineered multi-copper oxidase reporter of protein-protein interactions.

Barindra Sana, Sharon M Q Chee, Jantana Wongsantichon, Sarada Raghavan, Robert C Robinson, Farid J Ghadessy

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Barindra SanaFrom the p53 Laboratory, Agency for Science, Technology, and Research (A*STAR), 8A Biomedical Grove, Singapore 138648, Singapore.
Sharon M Q CheeFrom the p53 Laboratory, Agency for Science, Technology, and Research (A*STAR), 8A Biomedical Grove, Singapore 138648, Singapore.
Jantana Wongsantichonthe Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok 10400, Thailand, and.ORCID 0000-0002-4134-2248
Sarada RaghavanFrom the p53 Laboratory, Agency for Science, Technology, and Research (A*STAR), 8A Biomedical Grove, Singapore 138648, Singapore.
Robert C Robinsonthe Institute of Molecular and Cellular Biology, A*STAR, 61 Biopolis Drive, Singapore 138673, Singapore.
Farid J GhadessyFrom the p53 Laboratory, Agency for Science, Technology, and Research (A*STAR), 8A Biomedical Grove, Singapore 138648, Singapore, fghadessy@p53Lab.a-star.edu.sg.ORCID 0000-0001-8559-903X
Agency for Science, Technology and Research · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein-protein interactions (PPIs) are ubiquitous in almost all biological processes and are often corrupted in diseased states. A detailed understanding of PPIs is therefore key to understanding cellular physiology and can yield attractive therapeutic targets. Here, we describe the development and structural characterization of novel

Indexed as

Amino Acid SequenceCrystallography, X-RayEscherichia coliEscherichia coli ProteinsKineticsLigandsOxidoreductasesProtein BindingProtein ConformationProtein EngineeringProto-Oncogene Proteins c-mdm2Sequence Homology, Amino Acidcopper oxidaseEscherichia coli ProteinsLigandsOxidoreductasesProto-Oncogene Proteins c-mdm2antibodyCueOdrug screening toolenzyme mechanismenzyme mutationenzyme oxidaseMDM2 proto-oncogeneprotein engineeringprotein-protein interactionprotein sensorstructure-functionX-ray crystallography

Identifiers

PMID30770473
PMCPMC6497955
OpenAlexW2912276490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.