Evidence map›Paper›PMID 30770415›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Soluble Fc-Disabled Herpes Virus Entry Mediator Augments Activation and Cytotoxicity of NK Cells by Promoting Cross-Talk between NK Cells and Monocytes.

Qinglai Meng, Asifa K Zaidi, John Sedy, Armand Bensussan, Daniel L Popkin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Qinglai MengInstitute of Biomedical Sciences, Shanxi University, Xiaodian District, Taiyuan City, Shanxi Province 030006, China.
Asifa K ZaidiDepartment of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
John SedyInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.ORCID 0000-0002-6428-1054
Armand BensussanINSERM UMR 976, Hôpital Saint-Louis, 75475 Paris Cedex 10, France.ORCID 0000-0002-0409-2497
Daniel L PopkinDepartment of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; daniel.popkin@case.edu.
University School · USInserm · FRSanford Burnham Prebys Medical Discovery Institute · USShanxi University · CN

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Vitamin D endocrine system and Protection Against Skin TumorlgenesisP30AR039750 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1988 to 2015
$9.1M
Combating persistent viral infections using cell specific therapiesI01BX002719 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI POPKIN, DANIEL LEWIS · 2016 to 2018
–
BLRD VA I01 BX002719NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR002548NIAID NIH HHS P30 AI027767NIAMS NIH HHS P30 AR039750
6 · The paper itself

Abstract

CD160 is highly expressed by NK cells and is associated with cytolytic effector activity. Herpes virus entry mediator (HVEM) activates NK cells for cytokine production and cytolytic function via CD160. Fc-fusions are a well-established class of therapeutics, where the Fc domain provides additional biological and pharmacological properties to the fusion protein including enhanced serum

Indexed as

Antigens, CDCells, CulturedGPI-Linked ProteinsHumansImmunoglobulin Fc FragmentsImmunoglobulin GKiller Cells, NaturalLymphocyte ActivationMonocytesReceptor Cross-TalkReceptors, ImmunologicReceptors, Tumor Necrosis Factor, Member 14Signal TransductionAntigens, CDCD160 protein, humanGPI-Linked ProteinsImmunoglobulin Fc FragmentsImmunoglobulin GReceptors, ImmunologicReceptors, Tumor Necrosis Factor, Member 14TNFRSF14 protein, human

Identifiers

PMID30770415
PMCPMC6424646
OpenAlexW2911495837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.