Evidence map›Paper›PMID 30770407›Full record

ArticleApplied and environmental microbiology2019

Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK.

Ming Peng, Xiu-Lan Chen, Dian Zhang, Xiu-Juan Wang, Ning Wang, Peng Wang, Jonathan D Todd, Yu-Zhong Zhang, Chun-Yang Li

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Cupin-Type Dimethylsulfoniopropionate Lyase from Pelagibacter ubique (DddKAngewandte Chemie (International ed. in English) · 2025
    Article
  3. Cloning and expression of the dimethylsulfoniopropionate lyase geneCurrent research in microbial sciences · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ming PengMarine Biotechnology Research Center, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Xiu-Lan ChenMarine Biotechnology Research Center, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Dian ZhangMarine Biotechnology Research Center, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Xiu-Juan WangMarine Biotechnology Research Center, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Ning WangMarine Biotechnology Research Center, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Peng WangMarine Biotechnology Research Center, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Jonathan D ToddSchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.
Yu-Zhong ZhangMarine Biotechnology Research Center, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Chun-Yang LiMarine Biotechnology Research Center, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China lingdongzhihui@126.com.
State Key Laboratory of Microbial TechnologyShandong University · CNQingdao National Laboratory for Marine Science and Technology · CNUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The osmolyte dimethylsulfoniopropionate (DMSP) is produced in petagram quantities in marine environments and has important roles in global sulfur and carbon cycling. Many marine microorganisms catabolize DMSP via DMSP lyases, generating the climate-active gas dimethyl sulfide (DMS). DMS oxidation products participate in forming cloud condensation nuclei and, thus, may influence weather and climate. SAR11 bacteria are the most abundant marine heterotrophic bacteria; many of them contain the DMSP lyase DddK, and their

Indexed as

Catalytic DomainAlphaproteobacteriaAmino Acid SequenceBacteriaCarbon-Sulfur LyasesEscherichia coliGene Expression Regulation, BacterialModels, MolecularOceans and SeasPhylogenyPoint MutationProtein ConformationSeawaterSequence AlignmentSulfidesSulfonium CompoundsCarbon-Sulfur Lyasesdimethylpropiothetindimethyl sulfidedimethylsulfoniopropionate lyaseSulfidesSulfonium CompoundsSulfurWatercatalytic mechanismDMS generationDMSPDMSP lyase DddKSAR11

Identifiers

PMID30770407
PMCPMC6450030
OpenAlexW2913426860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.