ArticleNeuron2019
Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.
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In one paragraph
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
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Who cites it
48 citing papers in PubMed, 83 citations in OpenAlex.
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 3 institutions in 1 country.
Simone MayerEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: si.mayer@uni-tuebingen.de.
Jiadong ChenEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Dmitry VelmeshevEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Andreas MayerLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Ugomma C EzeEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Aparna BhaduriEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Carlos E CunhaEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Diane JungEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Arpana ArjunEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.
Emmy LiEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Beatriz AlvaradoEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Shaohui WangEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Nils LovegrenEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Michael L GonzalesFluidigm Corporation, South San Francisco, CA 94080, USA.
Lukasz SzpankowskiFluidigm Corporation, South San Francisco, CA 94080, USA.
Anne LeyratFluidigm Corporation, South San Francisco, CA 94080, USA.
Jay A A WestFluidigm Corporation, South San Francisco, CA 94080, USA.
Georgia PanagiotakosEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.
Arturo Alvarez-BuyllaEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Mercedes F ParedesEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Tomasz J NowakowskiEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Alex A PollenEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Arnold R KriegsteinEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: arnold.kriegstein@ucsf.edu.
Broad Center · USUniversity of California, San Francisco · USPrinceton University · US
Funding
Development and Expansion of the Human Cerebral CortexR35NS097305 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD · 2017 to 2024
$8.5MPREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7MA Cellular Resolution Census of the Developing Human BrainU01MH114825 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ERIC J, KRIEGSTEIN, ARNOLD · 2017 to 2021
$6.7MMapping the Developing Human Neocortex by Massively Parallel Single Cell AnalysisU01MH105989 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD · 2014 to 2016
$5.1MLate-migrating interneurons in the postnatal brainK08NS091537 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PAREDES, MERCEDES · 2015 to 2019
$968kMedical Research Council MR/R006237/1NICHD NIH HHS T32 HD007470NIMH NIH HHS U01 MH105989NIMH NIH HHS U01 MH114825NINDS NIH HHS K08 NS091537NINDS NIH HHS R35 NS097305
Abstract
In the developing human neocortex, progenitor cells generate diverse cell types prenatally. Progenitor cells and newborn neurons respond to signaling cues, including neurotransmitters. While single-cell RNA sequencing has revealed cellular diversity, physiological heterogeneity has yet to be mapped onto these developing and diverse cell types. By combining measurements of intracellular Ca
Indexed as
AnimalsBrainCalciumCell LineageEpendymoglial CellsGene Expression ProfilingGene Expression Regulation, DevelopmentalHumansMiceNeocortexNeurogenesisReceptor, Serotonin, 5-HT2ASequence Analysis, RNASerotoninSingle-Cell AnalysisCalciumReceptor, Serotonin, 5-HT2ASerotonincalcium imagingdifferentiationhuman neocortical developmentintermediate progenitor cellsneurogenesisneurotransmitterradial gliaradial glia scaffoldserotoninsingle-cell RNA sequencing
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.