Evidence map›Paper›PMID 30770136›Full record

ReviewTrends in neurosciences2019

Molecular Control of Oligodendrocyte Development.

Benayahu Elbaz, Brian Popko

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed.

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  15. Targeting enhancing myelin regeneration reverses cognitive deficits in a mouse model of intellectual disability.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  16. Article
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115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Benayahu ElbazThe Center for Peripheral Neuropathy, The Department of Neurology, University of Chicago, Chicago, IL, USA.
Brian PopkoThe Center for Peripheral Neuropathy, The Department of Neurology, University of Chicago, Chicago, IL, USA. Electronic address: bpopko@uchicago.edu.

Funding

Targeting the integrated stress response to protect oligodendrocyte lineage cells - Resubmission 01R01NS034939 · NINDS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI POPKO, BRIAN J · 1997 to 2024
$7.5M
ZFP24 Control of the myelination program of oligodendrocytesR01NS067550 · NINDS · UNIVERSITY OF CHICAGO · PI ELBAZ-EILON, BENAYAHU · 2009 to 2024
$3.4M
Reversible mRNA methylation in oligodendrocyte development and CNS myelinationR01NS109372 · NINDS · UNIVERSITY OF CHICAGO · PI POPKO, BRIAN J · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS034939NINDS NIH HHS R01 NS067550NINDS NIH HHS R01 NS109372
6 · The paper itself

Abstract

Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for the efficient propagation of action potentials. During developmental myelination of the central nervous system (CNS), oligodendrocyte progenitor cells (OPCs) proliferate and migrate to their final destination, where they terminally differentiate into mature oligodendrocytes and myelinate axons. Lineage progression and terminal differentiation of oligodendrocyte lineage cells are under tight transcriptional and post-transcriptional control. The characterization of several recently identified regulatory factors that govern these processes, which are the focus of this review, has greatly increased our understanding of oligodendrocyte development and function. These insights are critical to facilitate efforts to enhance OPC differentiation in neurological disorders that disrupt CNS myelin.

Indexed as

AnimalsCell DifferentiationHumansOligodendrogliamyelinoligodendrocyte lineage progressionoligodendrocytestranscription factors

Identifiers

PMID30770136
PMCPMC7397568

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.