ArticleGenes2019
Analysis of Topological Parameters of Complex Disease Genes Reveals the Importance of Location in a Biomolecular Network.
Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets.International journal of molecular sciences · 2023Review
- Network Biology-Inspired Machine Learning Features Predict Cancer Gene Targets and Reveal Target Coordinating Mechanisms.Pharmaceuticals (Basel, Switzerland) · 2023Article
- The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells.Developmental cell · 2022Article
- De novo individualized disease modules reveal the synthetic penetrance of genes and inform personalized treatment regimens.Genome research · 2022Article
- Phenotype correlations reveal the relationships of physiological systems underlying human ageing.Aging cell · 2021Article
- Exploring polyps to colon carcinoma voyage: can blocking the crossroad halt the sequence?Journal of cancer research and clinical oncology · 2021Review
- Gene expression profiling of corona virus microarray datasets to identify crucial targets in COVID-19 patients.Gene reports · 2021Article
- Screening and Identification of Survival-Associated Splicing Factors in Lung Squamous Cell Carcinoma.Frontiers in genetics · 2021Article
- Investigation of the Active Ingredients and Mechanism ofDrug design, development and therapy · 2021Article
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- Identifying Drug Targets in Pancreatic Ductal Adenocarcinoma Through Machine Learning, Analyzing Biomolecular Networks, and Structural Modeling.Frontiers in pharmacology · 2020Article
- A Seven-Long Non-coding RNA Signature Improves Prognosis Prediction of Lung Adenocarcinoma: An Integrated Competing Endogenous RNA Network Analysis.Frontiers in genetics · 2020Article
- Essential gene prediction inComputational and structural biotechnology journal · 2020Article
- G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence.Computational and structural biotechnology journal · 2019Review
- Identification of Hub Genes Associated With Progression and Prognosis in Patients With Bladder Cancer.Frontiers in genetics · 2019Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Network biology and medicine provide unprecedented opportunities and challenges for deciphering disease mechanisms from integrative viewpoints. The disease genes and their products perform their dysfunctions via physical and biochemical interactions in the form of a molecular network. The topological parameters of these disease genes in the interactome are of prominent interest to the understanding of their functionality from a systematic perspective. In this work, we provide a systems biology analysis of the topological features of complex disease genes in an integrated biomolecular network. Firstly, we identify the characteristics of four network parameters in the ten most frequently studied disease genes and identify several specific patterns of their topologies. Then, we confirm our findings in the other disease genes of three complex disorders (i.e., Alzheimer's disease, diabetes mellitus, and hepatocellular carcinoma). The results reveal that the disease genes tend to have a higher betweenness centrality, a smaller average shortest path length, and a smaller clustering coefficient when compared to normal genes, whereas they have no significant degree prominence. The features highlight the importance of gene location in the integrated functional linkages.
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