ArticleJournal of the American College of Surgeons2019
Enhancing Parathyroid Gland Visualization Using a Near Infrared Fluorescence-Based Overlay Imaging System.
Article in Journal of the American College of Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Near-infrared autofluorescence-based parathyroid glands identification in the thyroidectomy or parathyroidectomy: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2022Pooled it
- The Accuracy of Near Infrared Autofluorescence in Identifying Parathyroid Gland During Thyroid and Parathyroid Surgery: A Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Assessment of PTeye™ versus FLUOBEAM® LX for parathyroid adenomas: a pilot case-control study.Updates in surgery · 2025Trial
- Autofluorescence Imaging of Parathyroid and Thyroid Under Visible and Near-IR Light Excitation.Biosensors · 2025Article
- Will the autofluorescence take over inadvertent parathyroidectomy? Results from a multicentre cohort study.Updates in surgery · 2025Article
- The research progress of label-free optical imaging technology in intraoperative real-time navigation of parathyroid glands.Lasers in medical science · 2025Review
- Predictors of postoperative complications following thyroidectomy: A systematic review.Surgery in practice and science · 2024Review
- Feasibility of Autofluorescence Using Overlay Imaging for the Detection of Parathyroid Glands: Defining Standards.Annals of surgical oncology · 2024Article
- Resection of ectopic parathyroid adenomas within the carotid sheath-can fluorescence help the surgeon?Gland surgery · 2023Article
- Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications.Surgery · 2023Article
- Autofluorescence detection and co-axial projection for intraoperative localization of parathyroid gland.Biomedical engineering online · 2022Article
- Methylene Blue Near-Infrared Fluorescence Imaging in Breast Cancer Sentinel Node Biopsy.Cancers · 2022Article
- Targeted optical fluorescence imaging: a meta-narrative review and future perspectives.European journal of nuclear medicine and molecular imaging · 2021Review
- Fluorescence Image-Guided Surgery for Thyroid Cancer: Utility for Preventing Hypoparathyroidism.Cancers · 2021Review
- Current state of intraoperative use of near infrared fluorescence for parathyroid identification and preservation.Surgery · 2021Article
- Autofluorescence pattern of parathyroid adenomas.BJS open · 2021Article
- Detecting the Near Infrared Autofluorescence of the Human Parathyroid: Hype or Opportunity?Annals of surgery · 2020Review
- Methylene Blue-Current Knowledge, Fluorescent Properties, and Its Future Use.Journal of clinical medicine · 2020Review
- Pathological evaluation of the accuracy of a fluorescence spectroscopy system for detecting parathyroid glands.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundMisidentifying parathyroid glands (PGs) during thyroidectomies or parathyroidectomies could significantly increase postoperative morbidity. Imaging systems based on near infrared autofluorescence (NIRAF) detection can localize PGs with high accuracy. These devices, however, depict NIRAF images on remote display monitors, where images lack spatial context and comparability with actual surgical field of view. In this study, we designed an overlay tissue imaging system (OTIS) that detects tissue NIRAF and back-projects the collected signal as a visible image directly onto the surgical field of view instead of a display monitor, and tested its ability for enhancing parathyroid visualization. STUDY
designThe OTIS was first calibrated with a fluorescent ink grid and initially tested with parathyroid, thyroid, and lymph node tissues ex vivo. For in vivo measurements, the surgeon's opinion on tissue of interest was first ascertained. After the surgeon looked away, the OTIS back-projected visible green light directly onto the tissue of interest, only if the device detected relatively high NIRAF as observed in PGs. System accuracy was determined by correlating NIRAF projection with surgeon's visual confirmation for in situ PGs or histopathology report for excised PGs.
resultsThe OTIS yielded 100% accuracy when tested ex vivo with parathyroid, thyroid, and lymph node specimens. Subsequently, the device was evaluated in 30 patients who underwent thyroidectomy and/or parathyroidectomy. Ninety-seven percent of exposed tissue of interest was visualized correctly as PGs by the OTIS, without requiring display monitors or contrast agents.
conclusionsAlthough OTIS holds novel potential for enhancing label-free parathyroid visualization directly within the surgical field of view, additional device optimization is required for eventual clinical use.
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