ReviewGastroenterology2019
Organ Failure Due to Systemic Injury in Acute Pancreatitis.
Review in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 340 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
340 citing papers in PubMed, 6 syntheses or guidelines pooled it, 650 citations in OpenAlex.
- European Interdisciplinary Guidelines on Pain Management in Acute Pancreatitis: UEG, EPC, EDS, ESDO, EAGEN, ESPGHAN, ESGAR, and ESPCG Evidence-Based Recommendations.United European gastroenterology journal · 2026Guideline
- AEG-AESPANC-OPGE-SIED-SPG Ibero-Latin American Guidelines on Acute Pancreatitis (iLATAM-AP).United European gastroenterology journal · 2026Guideline
- Stem Cell-Derived Extracellular Vesicles for Acute Pancreatitis: a Systematic Review and Meta-analysis of Preclinical Studies.Stem cell reviews and reports · 2025Pooled it
- Predictive models for acute kidney injury in acute pancreatitis: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Global research trends in necrotizing pancreatitis: a bibliometric analysis from 2013 to 2024.Frontiers in medicine · 2025Pooled it
- Assessment of the efficacy of Chinese herbal medicine combined with western medicine for treating severe acute pancreatitis-related acute lung injury/acute respiratory distress syndrome: a systematic review and meta-analysis based on randomized controlled trials.Frontiers in pharmacology · 2025Pooled it
- Potential benefit of mirabilite external dressing combined with abdominal drainage in the early stage of severe acute pancreatitis.BMC gastroenterology · 2026Trial
- Gut microbiota dysbiosis exacerbates acute pancreatitis viaGut microbes · 2026Article
- A prognostic model based on metabolic indicators for recurrent acute pancreatitis in hypertriglyceridemia patients: a retrospective cohort study.Annals of medicine · 2026Article
- Time-series analysis of gene expression identifies of FKBP4 as a novel protective factor in severe acute pancreatitis-associated myocardial injury.Biochemistry and biophysics reports · 2026Article
- Zinc Transporter ZIP7 Is Associated with Intestinal Barrier Injury in Severe Acute Pancreatitis: Potential Roles in Mitochondrial Homeostasis and Ferroptosis.Digestive diseases and sciences · 2026Article
- Short-Term Alterations in Thiol-Disulfide Homeostasis Following ERCP: A Prospective Controlled Study.Digestive diseases and sciences · 2026Observational
- Hemoperfusion with Hemodiafiltration Versus Standard Medical Therapy for Severe Acute Pancreatitis: A Retrospective Study.Digestive diseases and sciences · 2026Article
- A Bar-Based Nomogram for Predicting Septic Shock in Patients with Acute Pancreatitis Complicated by Sepsis: Development and External Validation.Shock (Augusta, Ga.) · 2026Article
- Atrial fibrillation and cardiovascular comorbidity burden as predictors of in-hospital mortality in acute pancreatitis: A National Inpatient Sample analysis of 1.9 million hospitalizations.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Development and external evaluation of an interpretable machine-learning model for early prediction of organ failure in higher-risk acute pancreatitis patients: A multicentre cohort study.PLOS digital health · 2026Article
- Prediction of Severe Acute Pancreatitis at a Very Early Stage of the Disease Using Artificial Intelligence Techniques, Without Laboratory Data or Imaging Tests: The PANCREATIA Study.Annals of surgery · 2026Article
- Rhein alleviates acute pancreatitis by inhibiting TMAO-mediated inflammatory signaling pathways and reducing acinar cell injury.Journal of advanced research · 2026Article
- Machine learning model for early prediction of acute respiratory failure in acute pancreatitis: Multicenter validation.iScience · 2026Article
- Clinical characteristics of acute pancreatitis in patients with inflammatory bowel disease: a nationwide survey in Japan.Journal of gastroenterology · 2026Article
280 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure, which is seen in approximately 20% of all cases of acute pancreatitis and defines "severe acute pancreatitis." Organ failure typically develops early in the course of acute pancreatitis, but also may develop later due to infected pancreatic necrosis-induced sepsis. Organ failure is the most important determinant of outcome in acute pancreatitis. We review here the current understanding of the risk factors, pathophysiology, timing, impact on outcome, and therapy of organ failure in acute pancreatitis. As we discuss the pathophysiology of severe systemic injury, the distinctions between markers and mediators of severity are highlighted based on evidence supporting their causality in organ failure. Emphasis is placed on clinically relevant end points of organ failure and the mechanisms underlying the pathophysiological perturbations, which offer insight into potential therapeutic targets to treat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.