Evidence map›Paper›PMID 30768983›Full record

ArticleGastroenterology2019

Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8

Hadi Karimzadeh, Muthamia M Kiraithe, Valerie Oberhardt, Elahe Salimi Alizei, Jan Bockmann, Julian Schulze Zur Wiesch, Bettina Budeus, Daniel Hoffmann, Heiner Wedemeyer, Markus Cornberg and 19 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Hepatitis Delta Virus and Hepatocellular Carcinoma.Pathogens (Basel, Switzerland) · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Liver-Resident Bystander CD8Gastroenterology · 2021
    Article
  18. Review
  19. Human hepatitis D virus-specific T cell epitopes.JHEP reports : innovation in hepatology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 12 institutions in 5 countries.

Hadi KarimzadehInstitute of Virology, School of Medicine, Technical University of Munich/Helmholtz Zentrum München, Munich, Germany; Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; Department of Internal Medicine II, University Hospital Munich-Grosshadern, Munich, Germany.
Muthamia M KiraitheDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Valerie OberhardtDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany.
Elahe Salimi AlizeiDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Faculty of Chemistry and Pharmacy, University of Freiburg, Freiburg, Germany.
Jan BockmannDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany.
Julian Schulze Zur WieschDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany.
Bettina BudeusDepartment of Bioinformatics, University of Duisburg-Essen, Essen, Germany.
Daniel HoffmannDepartment of Bioinformatics, University of Duisburg-Essen, Essen, Germany.
Heiner WedemeyerGerman Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Department of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Markus CornbergGerman Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Adalbert KrawczykInstitute of Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; Department of Infectious Diseases, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Jassin Rashidi-AlavijehDepartment of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Francisco Rodríguez-FríasCIBERehd and Departments of Biochemistry/Microbiology and Hepatology, Vall d'Hebron Hospital, University Autónoma de Barcelona (UAB), Barcelona, Spain.
Rosario CasillasCIBERehd and Departments of Biochemistry/Microbiology and Hepatology, Vall d'Hebron Hospital, University Autónoma de Barcelona (UAB), Barcelona, Spain.
Maria ButiCIBERehd and Departments of Biochemistry/Microbiology and Hepatology, Vall d'Hebron Hospital, University Autónoma de Barcelona (UAB), Barcelona, Spain.
Antonina SmedileDepartment of Medical Sciences, University of Turin, Turin, Italy.
Seyed Moayed AlavianBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Andreas HeinoldInstitute of Transfusion Medicine, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Florian EmmerichInstitute for Transfusion Medicine and Gene Therapy, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Marcus PanningInstitute of Virology, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Emma GostickDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Jörg TimmInstitute of Virology, Heinrich-Heine-University, University Hospital, Duesseldorf, Germany.
Maike HofmannDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Bijan RaziorrouhDepartment of Internal Medicine II, University Hospital Munich-Grosshadern, Munich, Germany.
Robert ThimmeDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ulrike ProtzerInstitute of Virology, School of Medicine, Technical University of Munich/Helmholtz Zentrum München, Munich, Germany; German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany.
Michael RoggendorfInstitute of Virology, School of Medicine, Technical University of Munich/Helmholtz Zentrum München, Munich, Germany; Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany. Electronic address: michael.roggendorf@tum.de.
Christoph Neumann-HaefelinDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: christoph.neumann-haefelin@uniklinik-freiburg.de.
University of Freiburg · DEUniversity of Duisburg-Essen · DECentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESHelmholtz Zentrum München · DECardiff University · GBMedizinische Hochschule Hannover · DEUniversität Hamburg · DEBaqiyatallah University of Medical Sciences · IRDüsseldorf University Hospital · DEEssen University Hospital · DELMU Klinikum · DEUniversity of Turin · IT

Funding

Wellcome TrustWellcome Trust 100326Z/12/Z
6 · The paper itself

Abstract

BACKGROUND &

aimsHepatitis D virus (HDV) superinfection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no vaccine is available. Although HDV-specific CD8

methodsWe collected plasma and DNA samples from 104 patients with chronic HDV and HBV infection at medical centers in Europe and the Middle East, sequenced HDV, typed human leukocyte antigen (HLA) class I alleles from patients, and searched for polymorphisms in HDV RNA associated with specific HLA class I alleles. We predicted epitopes in HDV that would be recognized by CD8

resultsWe identified 21 polymorphisms in HDV that were significantly associated with specific HLA class I alleles (P < .005). Five of these polymorphisms were found to correspond to epitopes in HDV that are recognized by CD8

conclusionsWe analyzed sequences of HDV RNA and HLA class I alleles that present epitope peptides to CD8

Indexed as

AllelesCD8-Positive T-LymphocytesCell LineEpitopes, T-LymphocyteEvolution, MolecularHepatitis B, ChronicHepatitis D, ChronicHepatitis Delta VirusHLA-A AntigensHLA-B AntigensHumansImmune ToleranceImmunologic SurveillanceInterferon-gammaMutationPolymorphism, GeneticEpitopes, T-LymphocyteHLA-A AntigensHLA-B AntigensInterferon-gammaAntigen PresentationCytotoxic T CellMHC Class ITCR

Identifiers

PMID30768983
PMCPMC6486497
OpenAlexW2913700062

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.