Evidence map›Paper›PMID 30768948›Full record

ArticleMathematical biosciences2019

Predicting outcomes of chronic kidney disease from EMR data based on Random Forest Regression.

Jing Zhao, Shaopeng Gu, Adam McDermaid

Abstract read
In one paragraph

Article in Mathematical biosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jing ZhaoDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA; Sanford Research, Sioux Falls, SD 57104, USA. Electronic address: jing.zhao2@osumc.edu.
Shaopeng GuBioinformatics and Mathematical Biosciences Lab, Department of Mathematics and Statistics, South Dakota State University, Brookings, SD 57006, USA. Electronic address: shaopeng.gu@sdstate.edu.
Adam McDermaidBioinformatics and Mathematical Biosciences Lab, Department of Mathematics and Statistics, South Dakota State University, Brookings, SD 57006, USA. Electronic address: Adam.McDermaid@sdstate.edu.

Funding

Transdisciplinary approaches to American Indian and rural population health researchP20GM121341 · NIGMS · SANFORD RESEARCH/USD · PI ANGAL, JYOTI · 2017 to 2022
$11.8M
NIGMS NIH HHS P20 GM121341
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is prevalent across the world, and kidney function is well defined by an estimated glomerular filtration rate (eGFR). The progression of kidney disease can be predicted if the future eGFR can be accurately estimated using predictive analytics. In this study, we developed and validated a prediction model of eGFR by data extracted from a regional health system. This dataset includes demographic, clinical and laboratory information from primary care clinics. The model was built using Random Forest regression and evaluated using Goodness-of-fit statistics and discrimination metrics. After data preprocessing, the patient cohort for model development and validation contained 61,740 patients. The final model included eGFR, age, gender, body mass index (BMI), obesity, hypertension, and diabetes, which achieved a mean coefficient of determination of 0.95. The estimated eGFRs were used to classify patients into CKD stages with high macro-averaged and micro-averaged metrics. In conclusion, a model using real-world electronic medical records (EMR) data can accurately predict future kidney functions and provide clinical decision support.

Indexed as

Disease ProgressionModels, StatisticalOutcome Assessment, Health CareAdultAgedComorbidityElectronic Health RecordsFemaleGlomerular Filtration RateHumansMaleMiddle AgedPrognosisRenal Insufficiency, Chronic

Identifiers

PMID30768948
PMCPMC6435377

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.