Evidence map›Paper›PMID 30768789›Full record

ReviewClinical and experimental immunology2019

Neuroimmunology - the past, present and future.

E Nutma, H Willison, G Martino, S Amor

Registry-linked trialOpen access · greenAbstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and experimental immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07788573 (The Role of the FCRL5 Protein in the Pathophysiology of Multiple Sclerosis and Response to Treatment), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07788573 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Role of the FCRL5 Protein in the Pathophysiology of Multiple Sclerosis and Response to Treatment

TypeobservationalSponsorUniversité Catholique de LouvainRan2026 to 2029Enrolled90ConditionsMultiple SclerosisArmsA blood test every 6 months for MS patients., A single blood draw for the healthy volunteer, A single blood draw for the group of volunteers with Sjögren's syndrome
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
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  16. Article
  17. The Role of Gut Microbiota in Neuromyelitis Optica Spectrum Disorder.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Review
  20. Primary Literature for Teaching Neuroimmunology - An Instructor's Resource.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

E NutmaDepartment of Pathology, Amsterdam UMC, VUmc site, Amsterdam, the Netherlands.
H WillisonUniversity of Glasgow, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
G MartinoNeuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSpe), San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
S AmorDepartment of Pathology, Amsterdam UMC, VUmc site, Amsterdam, the Netherlands.ORCID 0000-0001-6169-9845
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLQueen Mary University of London · GBUniversity of Glasgow · GBVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroimmunology as a separate discipline has its roots in the fields of neurology, neuroscience and immunology. Early studies of the brain by Golgi and Cajal, the detailed clinical and neuropathology studies of Charcot and Thompson's seminal paper on graft acceptance in the central nervous system, kindled a now rapidly expanding research area, with the aim of understanding pathological mechanisms of inflammatory components of neurological disorders. While neuroimmunologists originally focused on classical neuroinflammatory disorders, such as multiple sclerosis and infections, there is strong evidence to suggest that the immune response contributes to genetic white matter disorders, epilepsy, neurodegenerative diseases, neuropsychiatric disorders, peripheral nervous system and neuro-oncological conditions, as well as ageing. Technological advances have greatly aided our knowledge of how the immune system influences the nervous system during development and ageing, and how such responses contribute to disease as well as regeneration and repair. Here, we highlight historical aspects and milestones in the field of neuroimmunology and discuss the paradigm shifts that have helped provide novel insights into disease mechanisms. We propose future perspectives including molecular biological studies and experimental models that may have the potential to push many areas of neuroimmunology. Such an understanding of neuroimmunology will open up new avenues for therapeutic approaches to manipulate neuroinflammation.

Indexed as

NeurologyAnimalsCentral Nervous SystemHistory, 20th CenturyHistory, 21st CenturyHumansInflammationMultiple SclerosisNeurodegenerative Diseasescentral nervous systeminflammationneurodegenerationneuroimmunologyneuroinflammation

Identifiers

PMID30768789
PMCPMC6693969
OpenAlexW2923978878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.