Evidence map›Paper›PMID 30768685›Full record

ArticleJournal of food science2019

Determination of Peptide Profile Consistency and Safety of Collagen Hydrolysates as Quality Attributes.

Carlos A López-Morales, Said Vázquez-Leyva, Luis Vallejo-Castillo, Gregorio Carballo-Uicab, Leslie Muñoz-García, José Enrique Herbert-Pucheta, L Gerardo Zepeda-Vallejo, Marco Velasco-Velázquez, Lenin Pavón, Sonia M Pérez-Tapia and 1 more

Abstract read
In one paragraph

Article in Journal of food science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. The Efficacy and Safety of CollaSel ProJournal of clinical medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carlos A López-MoralesUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.ORCID https://orcid.org/0000-0001-8111-3127
Said Vázquez-LeyvaUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.ORCID https://orcid.org/0000-0003-2625-1230
Luis Vallejo-CastilloUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.ORCID https://orcid.org/0000-0002-9532-3472
Gregorio Carballo-UicabUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.ORCID https://orcid.org/0000-0002-9458-0776
Leslie Muñoz-GarcíaUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.ORCID https://orcid.org/0000-0002-7817-8314
José Enrique Herbert-PuchetaConsejo Nacional de Ciencia y Tecnología-Laboratorio Nacional de Investigación y Servicio Agroalimentario Forestal, Univ. Autónoma de Chapingo, Chapingo, 56230, México.ORCID https://orcid.org/0000-0003-1727-2785
L Gerardo Zepeda-VallejoDepto. de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, 11340, México.ORCID https://orcid.org/0000-0001-6637-8565
Marco Velasco-VelázquezDepto. de Farmacología y Unidad Periférica de Investigación en Biomedicina Translacional (CMN 20 de noviembre ISSSTE), Facultad de Medicina, Univ. Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, 04510, México.ORCID https://orcid.org/0000-0001-9717-0265
Lenin PavónLaboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias del Insto. Nacional de Psiquiatría Ramón de la Fuente, Ciudad de México, 14370, México.ORCID https://orcid.org/0000-0002-6067-6868
Sonia M Pérez-TapiaUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.ORCID https://orcid.org/0000-0002-2818-8522
Emilio Medina-RiveroUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.ORCID https://orcid.org/0000-0001-8862-1378

Funding

Consejo Nacional de Ciencia y Tecnología 407865Consejo Nacional de Ciencia y Tecnología INFRA 269012
6 · The paper itself

Abstract

Collagen hydrolysates are dietary supplements used for nutritional and medical purposes. They are complex mixtures of low-molecular-weight peptides obtained from the enzymatic hydrolysis of collagen, which provide intrinsic batch-to-batch heterogeneity. In consequence, the quality of these products, which is related to the reproducibility of their mass distribution pattern, should be addressed. Here, we propose an analytical approach to determine the peptide pattern as a quality attribute of Colagenart®, a product containing collagen hydrolysate. In addition, we evaluated the safety by measuring the viability of two cell lines exposed to the product. The consistency of peptide distribution was determined using Size Exclusion Chromatography (SEC), Mass Spectrometry coupled to a reversed phase UPLC system (MS-RP-UPLC), and Shaped-pulse off-resonance water-presaturation proton nuclear magnetic resonance spectrometry [

Indexed as

Caco-2 CellsChromatography, GelCollagenFood SafetyHumansHydrolysisMagnetic Resonance SpectroscopyMass SpectrometryMolecular WeightPeptidesProtein HydrolysatesQuality ControlCollagenPeptidesProtein Hydrolysatescollagen hydrolysatesion mobility mass spectrometrynuclear magnetic resonancequality controlsize exclusion chromatography

Identifiers

PMID30768685
PMCPMC6593667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.