ArticlePLoS genetics2019
An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Terpene-Based Thiazole Hydrazines as Negative Allosteric Modulators of MRGPRX4: In Vitro Evaluation and Binding Site Analysis.ACS medicinal chemistry letters · 2025Article
- MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.Science translational medicine · 2024Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- The structure, function, and pharmacology of MRGPRs.Trends in pharmacological sciences · 2023Review
- Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice.Frontiers in neuroscience · 2022Article
- Affirming the Abuse Liability and Addiction Potential of Menthol: Differences in Subjective Appeal to Smoking Menthol Versus Non-Menthol Cigarettes Across African American and White Young Adult Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption.Frontiers in genetics · 2022Article
- Article
- Associations between chronic cigarette smoking and taste function: Results from the 2013-2014 national health and nutrition examination survey.Physiology & behavior · 2021Article
- Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.Scientific reports · 2021Article
- Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1.International journal of molecular sciences · 2021Review
- The signaling pathway and polymorphisms of Mrgprs.Neuroscience letters · 2021Review
- Alteration, Reduction and Taste Loss: Main Causes and Potential Implications on Dietary Habits.Nutrients · 2020Review
- The Impact of Electronic Nicotine Delivery System (ENDS) Flavors on Nicotinic Acetylcholine Receptors and Nicotine Addiction-Related Behaviors.Molecules (Basel, Switzerland) · 2020Review
- Article
- Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs.Nature structural & molecular biology · 2019Review
- MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
In the U.S., more than 80% of African-American smokers use mentholated cigarettes, compared to less than 30% of Caucasian smokers. The reasons for these differences are not well understood. To determine if genetic variation contributes to mentholated cigarette smoking, we performed an exome-wide association analysis in a multiethnic population-based sample from Dallas, TX (N = 561). Findings were replicated in an independent cohort of African Americans from Washington, DC (N = 741). We identified a haplotype of MRGPRX4 (composed of rs7102322[G], encoding N245S, and rs61733596[G], T43T), that was associated with a 5-to-8 fold increase in the odds of menthol cigarette smoking. The variants are present solely in persons of African ancestry. Functional studies indicated that the variant G protein-coupled receptor encoded by MRGPRX4 displays reduced agonism in both arrestin-based and G protein-based assays, and alteration of agonism by menthol. These data indicate that genetic variation in MRGPRX4 contributes to inter-individual and inter-ethnic differences in the preference for mentholated cigarettes, and that the existence of genetic factors predisposing vulnerable populations to mentholated cigarette smoking can inform tobacco control and public health policies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.