ArticlePancreas2019
Blood Urea Nitrogen Elevation Is a Marker for Pediatric Severe Acute Pancreatitis.
Article in Pancreas, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Etiology, case fatality, recurrence, and severity in pediatric acute pancreatitis: a meta-analysis of 48 studies.Pediatric research · 2022Pooled it
- Admission risk factors and predictors of moderate or severe pediatric acute pancreatitis: A systematic review and meta-analysis.Frontiers in pediatrics · 2022Pooled it
- Development and validation of dynamic clinical subphenotypes for acute pancreatitis using hematocrit and blood urea nitrogen trajectories in intensive care unit: a multicenter retrospective cohort study.Journal of advanced research · 2026Article
- Admission hematocrit and fluctuating blood urea nitrogen levels predict the efficacy of blood purification treatment in severe acute pancreatitis patients.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Acute Pancreatitis in Children: It's Not Just a Simple Attack.Gastroenterology · 2025Review
- Article
- Clinical and imaging predictors for the development of diabetes mellitus following a single episode of acute pancreatitis in youth.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2025Article
- Liberal Fluid Resuscitation is Associated with Improved Outcomes in Pediatric Acute Pancreatitis.The Journal of pediatrics · 2025Observational
- The Role of Pancreatitis Risk Genes in Endocrine Insufficiency Development After Acute Pancreatitis in Children.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Observational
- Nutritional parameters following first episode of pediatric acute pancreatitis.Clinical nutrition ESPEN · 2024Observational
- Computed Tomography Assessment of Severity of Acute Pancreatitis in Bangladeshi Children.Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Elevated BUN Upon Admission as a Predictor of in-Hospital Mortality Among Patients with Acute Exacerbation of COPD: A Secondary Analysis of Multicenter Cohort Study.International journal of chronic obstructive pulmonary disease · 2023Article
- Prediction of prognosis in patients with nontraumatic intracranial hemorrhage using blood urea nitrogen-to-creatinine ratio on admission: a retrospective cohort study based on data from the medical information Mart for intensive care-IV database.Frontiers in neurology · 2023Article
- High Rate of Islets Autoimmunity in Pediatric Patients with Index Admission of Acute Pancreatitis.Pediatric diabetes · 2023Article
- Ultrasound findings of acute pancreatitis in children.Pediatric radiology · 2022Article
- Matrix metalloproteinases and their inhibitors in pediatric severe acute pancreatitis.PloS one · 2022Article
- Clinical utility of the pancreatitis activity scoring system in severe acute pancreatitis.Frontiers in physiology · 2022Article
- Cytokine Profile Elevations on Admission Can Determine Risks of Severe Acute Pancreatitis in Children.The Journal of pediatrics · 2021Article
- Prevalence and impact of acute kidney injury in hospitalized pediatric patients with acute pancreatitis.Pediatric nephrology (Berlin, Germany) · 2021Article
- Early Changes in Blood Urea Nitrogen (BUN) Can Predict Mortality in Acute Pancreatitis: Comparative Study between BISAP Score, APACHE-II, and Other Laboratory Markers-A Prospective Observational Study.Canadian journal of gastroenterology & hepatology · 2021Observational
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe natural course of patients who develop acute pancreatitis (AP) can range from mild to severe acute pancreatitis (SAP). The aim of this study was to evaluate for early predictors of developing SAP during the first episode of AP in a prospective pediatric cohort.
methodsClinical data were prospectively collected and subsequently analyzed for pediatric patients presenting with their first episode of AP between March 2013 and January 2017 to Cincinnati Children's Hospital Medical Center.
resultsA total of 118 patients were included in the analysis, and 22 (18.6%) developed SAP. Patients who developed SAP had significantly higher values of blood urea nitrogen (BUN) (P = 0.007), magnesium (P = 0.04), glucose (P = 0.03), sodium (P = 0.03), and C-reactive protein (P = 0.02). A logistic regression model with BUN as a predictor of SAP was superior to any other combination of variables (area under the receiver operating characteristic curve, 0.75; 95% confidence interval, 0.61-0.89; sensitivity, 63%; specificity, 81%; positive predictive value, 43%; negative predictive value, 91%).
conclusionsThis study generated a predictive model using elevated BUN as a significant predictor of SAP. The findings are useful for early identification of pediatric patients at higher risk of developing SAP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.