Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2019
Trajectories of Symptom Change in the Treatment for Adolescents With Depression Study.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00006286 (Treatment for Adolescents With Depression Study), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment for Adolescents With Depression Study (TADS)
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Comparative efficacy of antidepressant medication for adolescent depression: a network meta-analysis and systematic review.BMC psychiatry · 2025Pooled it
- A systematic review exploring characteristics of youth with severe and enduring mental health problems (SEMHP).European child & adolescent psychiatry · 2024Pooled it
- Trajectories of Symptom Change in School-Based Prevention Programs for Adolescent Girls with Subclinical Depression.Journal of youth and adolescence · 2022Trial
- Trajectories of depression symptom change during and following treatment in adolescents with unipolar major depression.Journal of child psychology and psychiatry, and allied disciplines · 2020Trial
- Contribution of Longitudinal Mobile Health Measures in the Dynamic Track of Patients With Major Depressive Disorder: Multiple Centers, Prospective Cohort Study Using Functional Data Analysis and Machine Learning.JMIR mHealth and uHealth · 2026Article
- Development and validation evaluation of the depressive disorders self-management scale for adolescents.BMC psychology · 2026Article
- Real-World Symptom Trajectories in Adolescents With and Without Suicide Risk Receiving Care from Rula Health: Retrospective Study.JMIR pediatrics and parenting · 2025Article
- Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence.Molecular psychiatry · 2025Article
- Identifying latent subtypes of symptom trajectories in major depressive disorder patients and their predictors.European archives of psychiatry and clinical neuroscience · 2025Article
- The trajectory of depressive symptoms and the association with quality of life and suicidal ideation in patients with major depressive disorder.BMC psychiatry · 2025Article
- Changed sleep according to weighted blanket adherence in a 16-week sleep intervention among children with attention-deficit/hyperactivity disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Trajectories of depressive symptom and its association with air pollution: evidence from the Mr. OS and Ms. OS Hong Kong cohort study.BMC geriatrics · 2024Article
- The comparative study of chronically ill and healthy children and adolescents in the light of their general mental health.Scientific reports · 2024Article
- Treatment and Outcomes Among North Carolina Medicaid-Insured Youth With Depression.JAACAP open · 2023Article
- Descriptive analysis of depression among adolescents in Huangshi, China.BMC psychiatry · 2023Article
- Youth Top Problems and Early Treatment Response to the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents.Child psychiatry and human development · 2022Article
- Adolescent Health on Social Media and the Mentorship of Youth Investigators: Five Content Analysis Studies Conducted by Youth Investigators.JMIR mental health · 2021Article
- Depressive symptom severity mediates the association between avoidant problem-solving style and suicidal ideation.Journal of affective disorders · 2020Article
- Annual Research Review: Defining and treating pediatric treatment-resistant depression.Journal of child psychology and psychiatry, and allied disciplines · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveDepression is the most prominent mental health disorder among youth and has a profound impact with respect to morbidity and mortality if not addressed. The Treatment for Adolescent Depression Study (TADS) is one of the largest randomized controlled trials that compared the effectiveness of four treatments: cognitive-behavioral therapy (CBT); fluoxetine (FLX); combined cognitive-behavioral and fluoxetine treatment (COMB); and placebo (PBO). However, meaningful heterogeneous treatment courses are masked by these group mean comparisons of treatment impact. The present study sought to characterize the acute phase symptom trajectories of the depressed teens enrolled in TADS and to explore predictors of these trajectories, including TADS treatment condition.
methodThe TADS sample of 439 adolescent participants diagnosed with major depressive disorder was subjected to growth mixture modeling (GMM) to evaluate subgroups of adolescents with unique trajectories of depression symptom change.
resultsGrowth mixture modeling revealed three unique classes of adolescents: (1) a high-severity class with early significant improvement; (2) a high-severity class with limited symptom change; and (3) a moderate severity class with late significant improvement. Baseline predictors of class membership included treatment condition, sex, age, stage of change, depression severity, number of comorbid disorders, hopelessness, melancholia, suicidality, and cognitive distortions.
conclusionResults of this study may have implications for the selection of which treatment to use for which depressed adolescent. CLINICAL TRIAL REGISTRATION INFORMATION: Treatment for Adolescents With Depression Study (TADS); https://clinicaltrials.gov/; NCT00006286.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.