Evidence map›Paper›PMID 30768405›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2019

Prescription Drug Misuse: Sources of Controlled Medications in Adolescents.

Ty S Schepis, Timothy E Wilens, Sean Esteban McCabe

Abstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  10. The burden of acute pain in the U.S. in the wake of the opioid crisis.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Ty S SchepisTexas State University, San Marcos, Texas. Electronic address: schepis@txstate.edu.
Timothy E WilensMassachusetts General Hospital, Boston, and Harvard Medical School, Cambridge, MA.
Sean Esteban McCabeCenter for the Study of Drugs, Alcohol, Smoking and Health, School of Nursing, University of Michigan, Ann Arbor, and the Institute for Research on Women and Gender, University of Michigan, Ann Arbor.

Funding

Trajectories of Prescription Nonmedical Drug MisuseR01DA031160 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEAN ESTEBAN MCCABE · 2011 to 2026
$3.7M
Prescription Drug Misuse Characteristics in Adolescents and Young Adults: Influence of School EnrollmentR01DA043691 · NIDA · TEXAS STATE UNIVERSITY · PI TY Stephen SCHEPIS · 2017 to 2026
$1.8M
NIDA NIH HHS R01 DA031160NIDA NIH HHS R01 DA043691
6 · The paper itself

Abstract

objectiveAdolescent controlled prescription drug misuse (PDM) co-occurs with significant consequences, including lower educational achievement, substance use disorder (SUD) symptoms, and psychopathology. Nonetheless, adolescent PDM sources and the prevalence of other substance use, SUD, and mental health outcomes associated with sources remain poorly understood.

methodData were from the 2009 to 2014 National Survey on Drug Use and Health, including 103,920 adolescents (12-17 years of age). Six mutually exclusive sources were used: physician source only, theft/fake prescription only, friend/relative for free only, purchases only, other source only, or multiple sources. Analyses occurred separately for prescription opioids, stimulants, and tranquilizer/sedatives. PDM source prevalence across adolescents and by sex and school enrollment/engagement were estimated. Adjusted odds of past-year DSM-IV substance-specific SUD, marijuana use, any SUD, major depressive disorder (MDD), anxiety diagnosis, mental health treatment, and past-month binge drinking were estimated by source.

resultsFriends/relatives, for free, was the most common source (29.0%-33.2%), followed by physician sources for opioids (23.9%), purchases for stimulants (23.5%), and tranquilizer/sedatives (22.7%). Few school enrollment/engagement differences existed, but female adolescents were more likely to use multiple sources. Over 70% of adolescents using multiple sources had a past-year SUD. Multiple sources, purchases, and theft/fake prescription were more strongly associated with other substance use than physician source use, and multiple source use was linked with MDD.

conclusionAdolescents using multiple sources, purchases and theft/fake prescriptions have elevated rates of other substance use, SUD and MDD and particularly warrant intervention. Also, adolescents with other SUD and MDD should be screened for PDM and misuse sources.

Indexed as

AdolescentAnalgesics, OpioidCentral Nervous System StimulantsChildFemaleHealth SurveysHumansHypnotics and SedativesLogistic ModelsMajor Depressive DisorderMalePrescription Drug MisusePrescription DrugsStudent DropoutsSubstance-Related DisordersTranquilizing AgentsAnalgesics, OpioidCentral Nervous System StimulantsHypnotics and SedativesPrescription DrugsTranquilizing Agentsopioidsourcestimulanttranquilizer

Identifiers

PMID30768405
PMCPMC6491250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.