Evidence map›Paper›PMID 30768396›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2019

Structural Brain Alterations in Youth With Psychosis and Bipolar Spectrum Symptoms.

Maria Jalbrzikowski, David Freedman, Catherine E Hegarty, Eva Mennigen, Katherine H Karlsgodt, Loes M Olde Loohuis, Roel A Ophoff, Raquel E Gur, Carrie E Bearden

Erratum issuedAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  7. The relationship between brain structure and general psychopathology in preadolescents.Journal of child psychology and psychiatry, and allied disciplines · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Maria JalbrzikowskiUniversity of Pittsburgh, PA. Electronic address: jalbrzikowskime@upmc.edu.
David FreedmanSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles.
Catherine E HegartyUniversity of California, Los Angeles.
Eva MennigenSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles.
Katherine H KarlsgodtUniversity of California, Los Angeles.
Loes M Olde LoohuisCenter for Neurobehavioral Genetics, University of California, Los Angeles.
Roel A OphoffSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; Center for Neurobehavioral Genetics, University of California, Los Angeles.
Raquel E GurLifespan Brain Institute, Penn Medicine and Children's Hospital of Philadelphia, University of Pennsylvania, PA.
Carrie E BeardenSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; Center for Neurobehavioral Genetics, University of California, Los Angeles; University of California, Los Angeles.
University of California, Los Angeles · USChildren's Hospital of Philadelphia · USUniversity of Pittsburgh · US

Funding

Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M
Training Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4M
Genetic Risk for Developmental Expression of Neuropsychiatric Intermediate TraitsR01MH107250 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2015 to 2017
$1.7M
Neurodevelopmental variation of intrinsic functional connectivity and its relationship to psychosis risk and gene expression - SupplementK01MH112774 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JALBRZIKOWSKI, MARIA · 2017 to 2022
$884k
Accelerating the diagnosis of bipolar disorder using genetic and phenotypic signaturesK99MH116115 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLDE LOOHUIS, LOES MARLEIN · 2018 to 2019
$257k
NIMH NIH HHS K01 MH112774NIMH NIH HHS K99 MH116115NIMH NIH HHS R01 MH107250NIMH NIH HHS RC2 MH089983NIMH NIH HHS T32 MH073526
6 · The paper itself

Abstract

objectiveAdults with established diagnoses of serious mental illness (bipolar disorder and schizophrenia) exhibit structural brain abnormalities, yet less is known about how such abnormalities manifest earlier in development.

methodCross-sectional data publicly available from the Philadelphia Neurodevelopmental Cohort (PNC) were analyzed. Structural magnetic resonance neuroimaging data were collected on a subset of the PNC (N = 989; 9-22 years old). Cortical thickness, surface area (SA), and subcortical volumes were calculated. Study participants were assessed for psychiatric symptomatology using a structured interview and the following groups were created: typically developing (n = 376), psychosis spectrum (PS; n = 113), bipolar spectrum (BP; n = 117), and BP + PS (n = 109). Group and developmental differences in structural magnetic resonance neuroimaging measures were examined. In addition, the extent to which any structural aberration was related to neurocognition, global functioning, and clinical symptomatology was examined.

resultsCompared with other groups, PS youth exhibited significantly decreased SA in the orbitofrontal, cingulate, precentral, and postcentral regions. PS youth also exhibited deceased thalamic volume compared with all other groups. The strongest effects for precentral and posterior cingulate SA decreases were seen during early adolescence (13-15 years old) in PS youth. The strongest effects for decreases in thalamic volume and orbitofrontal and postcentral SA were observed in mid-adolescence (16-18 years) in PS youth. Across groups, better overall functioning was associated with increased lateral orbitofrontal SA. Increased postcentral SA was associated with better executive cognition and less severe negative symptoms in the entire sample.

conclusionIn a community-based sample, decreased cortical SA and thalamic volume were present early in adolescent development in youth with PS symptoms, but not in youth with BP symptoms or with BP and PS symptoms. These findings point to potential biological distinctions between PS and BP conditions, which could suggest additional biomarkers relevant to early identification.

Indexed as

AdolescentBipolar DisorderBrainChildCohort StudiesCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMalePhiladelphiaPsychotic DisordersTomography, X-Ray ComputedYoung Adultcortical thicknessdevelopmentneuroimagingschizophreniasurface area

Identifiers

PMID30768396
PMCPMC7110691
OpenAlexW2950211779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.