Evidence map›Paper›PMID 30768394›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2019

A Multisite Randomized Controlled Two-Phase Trial of the Early Start Denver Model Compared to Treatment as Usual.

Sally J Rogers, Annette Estes, Catherine Lord, Jeff Munson, Marie Rocha, Jamie Winter, Jessica Greenson, Costanza Colombi, Geraldine Dawson, Laurie A Vismara and 4 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00698997 (Intensive Intervention for Toddlers With Autism), which is not on this map. Cited by 88 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 9 pooled it
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00698997 nacompletednot on this map

Intensive Intervention for Toddlers With Autism

TypeinterventionalSponsorUniversity of California, DavisRan2008 to 2013Enrolled118ConditionsAutism, Autism Spectrum DisorderArmsEarly Start Denver Model, Standard community care
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 9 syntheses or guidelines pooled it, 225 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Intervention Effects on Language in Children With Autism: A Project AIM Meta-Analysis.Journal of speech, language, and hearing research : JSLHR · 2020
    Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Article
  20. Through Parents' Eyes: Perspectives on Child Development and Family Experience During ESDM Intervention.Autism research : official journal of the International Society for Autism Research · 2026
    Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Sally J RogersUniversity of California, Davis, MIND Institute, Sacramento. Electronic address: sjrogers@ucdavis.edu.
Annette EstesUniversity of Washington, Seattle.
Catherine LordWeill Cornell Medicine, Cornell University, New York, NY.
Jeff MunsonUniversity of Washington, Seattle.
Marie RochaUniversity of California, Davis, MIND Institute, Sacramento.
Jamie WinterWeill Cornell Medicine, Cornell University, New York, NY.
Jessica GreensonUniversity of Washington, Seattle.
Costanza ColombiUniversity of Michigan, Ann Arbor.
Geraldine DawsonDuke University, Durham, NC.
Laurie A VismaraUniversity of California, Davis, MIND Institute, Sacramento.
Catherine A SugarUniversity of California, Los Angeles.
Gerhard HellemannUniversity of California, Los Angeles.
Fiona WhelanUniversity of California, Los Angeles.
Meagan TalbottUniversity of California, Davis, MIND Institute, Sacramento.
University of California, Davis · USSeattle University · USUniversity of California, Los Angeles · USCornell University · USDuke University · USUniversity of Michigan–Ann Arbor · US

Funding

A Multi-Site Randomized Study of Intensive Treatment for Toddlers with AutismR01MH081757 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ROGERS, SALLY J · 2007 to 2011
$14.8M
NIMH NIH HHS R01 MH081757
6 · The paper itself

Abstract

objectiveThis single-blind, randomized, multisite, intent-to-treat study was designed to replicate and extend Dawson et al.'s (Pediatrics. 2010;125: e17-e23) randomized controlled trial testing the effects of the Early Start Denver Model (ESDM), an intensive play- and routines-based intervention delivered in natural settings.

methodA randomized controlled trial was conducted at 3 universities. One hundred eighteen children 14 to 24 months old with autism spectrum disorder were enrolled and randomly assigned to ESDM or community interventions for 27 months. Eighty-one children completed the full treatment course and all assessments; data from all 118 children were used in analyses. Children assigned to the ESDM intervention received 3 months of weekly parent coaching followed by 24 months of 15 hour per week (on average) 1:1 treatment weekly on average in homes or daycare settings from supervised therapy assistants while parents received coaching 4 hours monthly from a certified ESDM therapist.

resultsFor the primary analyses, there were time-by-group and time-by-group-by-site interactions for language outcome. In the significant 3-way interaction involving site, 2 sites showed a significant ESDM advantage and the third site showed no significant group differences. In the planned 2-way analysis that pooled data across all 3 sites, there was a significant advantage found for the ESDM group. For the secondary analyses, there were no significant differences between the ESDM and community groups involving developmental quotient, autism severity, or adaptive behavior. The treatment effect of group on language outcomes was not moderated by baseline developmental quotient, autism severity, or language.

conclusionResults of the primary analysis provide a partial replication of Dawson et al.'s 2010 language findings. CLINICAL TRIAL REGISTRATION INFORMATION: Intensive Intervention for Toddlers with Autism; https://clinicaltrials.gov/; NCT00698997.

Indexed as

Parent-Child RelationsAutism Spectrum DisorderChild, PreschoolEarly Intervention, EducationalFamily TherapyFemaleHumansInfantMaleModels, PsychologicalParentsRiskTime FactorsUnited Statesautism spectrum disorderdevelopmental quotient (DQ)early interventionEarly Start Denver Model (ESDM)toddlers

Identifiers

PMID30768394
PMCPMC12088912
OpenAlexW2913192595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.