ArticleJournal of the American Academy of Child and Adolescent Psychiatry2019
Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Tangent space functional reconfigurations in individuals at risk for alcohol use disorder.Network neuroscience (Cambridge, Mass.) · 2025Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- Article
- Family History of Alcohol Use Disorder as a Predictor of Endogenous Pain Modulation Among Moderate to Heavy Drinkers.The journal of pain · 2022Article
- White matter integrity and functional connectivity in adolescents with a parental history of substance use disorder.Neuroimage. Reports · 2021Article
- Functional connectivity in frontostriatal networks differentiate offspring of parents with substance use disorders from other high-risk youth.Drug and alcohol dependence · 2021Article
- Risk and resilience for alcohol use disorder revealed in brain functional connectivity.NeuroImage. Clinical · 2021Article
- The disengaging brain: Dynamic transitions from cognitive engagement and alcoholism risk.NeuroImage · 2020Article
- Morphometric Biomarkers of Adolescents With Familial Risk for Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2019Article
- Editorial: Understanding the Child at Risk for Substance Use Disorders: Neuroimaging Addiction Risk.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveYouth with a family history of alcohol use disorder (family history positive [FHP]) are at increased risk for developing maladaptive substance use relative to family history negative (FHN) peers. Building on earlier studies demonstrating morphological differences and distinct patterns of neural activation in FHP, the purpose of the present study was to investigate differential intrinsic functional connectivity among brain networks indexing premorbid risk of developing alcohol use disorder (AUD).
methodThe current study examined intrinsic functional connectivity using resting state functional magnetic resonance imaging in 191 adolescents 13 to 18 years of age with and without family history of AUD via independent component analysis, a method enabling data-driven investigation of internetwork and intranetwork connectivity among brain regions at rest.
resultsAnalyses revealed significantly lower intranetwork connectivity in FHP compared to FHN participants between the dorsal premotor cortex and other sensorimotor network regions. Reduced intranetwork connectivity in this region was further correlated with the number of biological family members with AUD and mood disorders. Robust differences were also evident in internetwork connectivity as a function of age. However, there was no evidence for family history by age interactions.
conclusionIntra- but not internetwork connectivity appears to differentiate FHP and FHN adolescents, whereas age differences within adolescence are marked by differences in internetwork connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.