ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020
Dietary protein intake and kidney function decline after myocardial infarction: the Alpha Omega Cohort.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Modifiable Lifestyle Factors for Primary Prevention of CKD: A Systematic Review and Meta-Analysis.Journal of the American Society of Nephrology : JASN · 2021Pooled it
- The effect of protein and essential amino acid supplementation on muscle strength and performance in patients with chronic heart failure: a systematic review.European journal of nutrition · 2020Pooled it
- High-Protein Intake Impact on Human and Animal Kidney Function Across the Lifespan: Clinical Evidence and Emerging Concepts.Nutrients · 2026Review
- Higher habitual protein intake is not linked to decline of iohexol-measured GFR in adults ≥40 years.Clinical kidney journal · 2026Article
- Dietary Protein Intake in CKD: Quantity and Quality.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- Assessment, molecular mechanisms and therapeutic targets for renal functional reserve.Renal failure · 2025Review
- Low-protein diet for chronic kidney disease: Evidence, controversies, and practical guidelines.Journal of internal medicine · 2025Review
- Adhering to recommended dietary protein intake for optimizing human health benefitsRSC advances · 2025Review
- Dietary Guidelines Post Kidney Transplant: Is This the Missing Link in Recovery and Graft Survival?Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
- Associations between in-hospital daily protein intake and adverse clinical outcomes in older patients with heart failure.ESC heart failure · 2024Article
- High Protein Diets and Glomerular Hyperfiltration in Athletes and Bodybuilders: Is Chronic Kidney Disease the Real Finish Line?Sports medicine (Auckland, N.Z.) · 2024Review
- The case for a ketogenic diet in the management of kidney disease.BMJ open diabetes research & care · 2024Review
- Correlation between fruit consumption and 10-year all-cause mortality in patients with dyslipidemia.Frontiers in nutrition · 2024Article
- What is central to renal nutrition: protein or sodium intake?Clinical kidney journal · 2023Review
- Analysis of different plant- and animal-based dietary patterns and their relationship with serum uric acid levels in Chinese adults.Nutrition journal · 2023Article
- Is high protein intake a real concern for healthy kidneys?Journal of nephrology · 2023Article
- Plant-Dominant Low Protein Diet: A Potential Alternative Dietary Practice for Patients with Chronic Kidney Disease.Nutrients · 2023Review
- A Specific High-Protein Weight Loss Program Does Not Impair Renal Function in Patients Who Are Overweight/Obese.Nutrients · 2022Article
- Baohe pill decoction for diarrhea induced by high-fat and high-protein diet is associated with the structure of lactase-producing bacterial community.Frontiers in cellular and infection microbiology · 2022Article
- Protein Intake and Human Health: Implications of Units of Protein Intake.Advances in nutrition (Bethesda, Md.) · 2021Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPost-myocardial infarction (MI) patients have a doubled rate of kidney function decline compared with the general population. We investigated the extent to which high intake of total, animal and plant protein are risk factors for accelerated kidney function decline in older stable post-MI patients.
methodsWe analysed 2255 post-MI patients (aged 60-80 years, 80% men) of the Alpha Omega Cohort. Dietary data were collected with a biomarker-validated 203-item food frequency questionnaire. At baseline and 41 months, we estimated glomerular filtration rate based on the Chronic Kidney Disease Epidemiology Collaboration equations for serum cystatin C [estimated glomerular filtration rate (eGFRcysC)] alone and both creatinine and cystatin C (eGFRcr-cysC).
resultsMean [standard deviation (SD)] baseline eGFRcysC and eGFRcr-cysC were 82 (20) and 79 (19) mL/min/1.73 m2. Of all patients, 16% were current smokers and 19% had diabetes. Mean (SD) total protein intake was 71 (19) g/day, of which two-thirds was animal and one-third plant protein. After multivariable adjustment, including age, sex, total energy intake, smoking, diabetes, systolic blood pressure, renin-angiotensin system blocking drugs and fat intake, each incremental total daily protein intake of 0.1 g/kg ideal body weight was associated with an additional annual eGFRcysC decline of -0.12 (95% confidence interval -0.19 to -0.04) mL/min/1.73 m2, and was similar for animal and plant protein. Patients with a daily total protein intake of ≥1.20 compared with <0.80 g/kg ideal body weight had a 2-fold faster annual eGFRcysC decline of -1.60 versus -0.84 mL/min/1.73 m2. Taking eGFRcr-cysC as outcome showed similar results. Strong linear associations were confirmed by restricted cubic spline analyses.
conclusionA higher protein intake was significantly associated with a more rapid kidney function decline in post-MI patients.
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