ArticleJAMA network open2019
Use of Prescription Opioids and Initiation of Fatal 2-Vehicle Crashes.
Article in JAMA network open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- An Open-Road Driving Performance Task to Examine Long-Term Medical Marijuana Use and Prescription Opioid Positivity Among Adults Aged 50 Years and Older: Protocol for an Observational Trial.JMIR research protocols · 2025Article
- Effects of state opioid prescribing laws on rates of fatal crashes in the USA.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2025Article
- Article
- Article
- Trends in Prescription Opioid Use in Motor Vehicle Crash Injuries in the United States: 2014-2018.International journal of environmental research and public health · 2022Article
- Do opioid prescriptions lead to fatal car crashes?American journal of health economics · 2022Article
- New Opioid Use and Risk of Emergency Department Visits Related to Motor Vehicle Collisions in Ontario, Canada.JAMA network open · 2021Article
- Potentially Inappropriate Medication Use and Hard Braking Events in Older Drivers.Geriatrics (Basel, Switzerland) · 2021Article
- Return to Driving After Anterior Cruciate Ligament Reconstruction: A Systematic Review.Orthopaedic journal of sports medicine · 2021Review
- The impact of high-dose opioid prescription on mortality rates among people living with HIV: A retrospective cohort study.The International journal on drug policy · 2020Article
- Review
- The Trends in Opioid Use in Castile and Leon, Spain: A Population-Based Registry Analysis of Dispensations in 2015 to 2018.Journal of clinical medicine · 2019Article
- Validation of not-at-fault driver representativeness assumption for quasi-induced exposure using U.S. national traffic databases.Journal of safety research · 2019Article
- Positive drug test trends in fatally-injured drivers in the United States from 2007 to 2017.Substance abuse treatment, prevention, and policy · 2019Article
- State marijuana laws and opioid overdose mortality.Injury epidemiology · 2019Review
- Prescription opioids, alcohol and fatal motor vehicle crashes: a population-based case-control study.Injury epidemiology · 2019Article
- Self-Reported Opioid Use and Driving Outcomes among Older Adults: The AAA LongROAD Study.Journal of the American Board of Family Medicine : JABFMArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Importance: The prevalence of prescription opioids detected in fatally injured drivers has increased markedly in the past 2 decades in the United States. It is unclear whether driver use of prescription opioids plays a role in fatal crash causation. Objective: To assess the association between driver use of prescription opioids and the risk of being culpable of crash initiation in fatal 2-vehicle crashes. Design, Setting, and Participants: This pair-matched study was based on data from the Fatality Analysis Reporting System for drivers involved in fatal 2-vehicle crashes on US public roads between January 1, 1993, and December 31, 2016. Data analysis was conducted from December 8, 2017, to December 7, 2018. Exposures: Testing positive for prescription opioids compared with testing negative, and blood alcohol concentrations (BACs) based on toxicological testing results. Main Outcomes and Measures: Culpability of crash initiation and adjusted odds ratios and 95% CIs. Results: A total of 36 642 drivers involved in 18 321 fatal 2-vehicle crashes were included. The most common driving error leading to fatal 2-vehicle crashes was failure to keep in lane (7535 [41%]). Drivers culpable of initiating the crashes were more likely than their nonculpable counterparts to test positive for prescription opioids (918 [5.0%] vs 549 [3.0%]; P < .001), alcohol (BAC ≥0.01 g/dL, 5258 [28.7%] vs 1815 [9.9%]; P < .001), and both substances (1.0% vs 0.3%, P < .001). The adjusted odds ratio of crash initiation was 2.18 (95% CI, 1.91-2.48) for drivers testing positive for prescription opioids compared with drivers testing negative, and increased with BACs (BAC 0.01-0.07 g/dL: adjusted odds ratio, 1.97; 95% CI, 1.75-2.22; BAC ≥0.08 g/dL: adjusted odds ratio, 8.20; 95% CI, 7.42-9.07; compared with BAC <0.01 g/dL). There was no significant interaction effect on crash initiation between prescription opioid use and alcohol use. Conclusions and Relevance: Driver use of prescription opioids was associated with initiation of 2-vehicle crashes, independent of alcohol use. Clinicians should take into consideration the adverse effect of opioid analgesics on driving safety while prescribing these medications and counseling patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.