ArticleGenome biology and evolution2019
Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee's Social Immune System.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- ReSkmer: modeling repeats allows k-mer-based alignment-free methods to calculate population genomic distances.Genome biology · 2026Article
- Establishing standards for genome wide association studies in eusocial insects through a case study in honey bees.Scientific reports · 2026Article
- The Evolution of Bees: Insights from 'Omic Studies.Genome biology and evolution · 2026Review
- Formic Acid-Based Preparation inInsects · 2025Article
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- Exploring the genetics of social behaviour in C. calcarata.Scientific reports · 2025Article
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- Accurate Detection ofEcology and evolution · 2024Article
- HBeeID: a molecular tool that identifies honey bee subspecies from different geographic populations.BMC bioinformatics · 2024Article
- Population-wide modelling reveals prospects of marker-assisted selection for parasitic mite resistance in honey bees.Scientific reports · 2024Article
- AmelHap: Leveraging drone whole-genome sequence data to create a honey bee HapMap.Scientific data · 2023Article
- Impaired immune function accompanies social evolution in spiders.Biology letters · 2022Article
- Haploid and Sexual Selection Shape the Rate of Evolution of Genes across the Honey Bee (Apis mellifera L.) Genome.Genome biology and evolution · 2022Article
- Host-pathogen protein-nucleic acid interactions: A comprehensive review.Computational and structural biotechnology journal · 2022Review
- Thrice out of Asia and the adaptive radiation of the western honey bee.Science advances · 2021Article
- A brief history and popularity of methods and tools used to estimate micro-evolutionary forces.Ecology and evolution · 2021Review
- Improved Apis mellifera reference genome based on the alternative long-read-based assemblies.G3 (Bethesda, Md.) · 2021Article
- Bidirectional interactions between host social behaviour and parasites arise through ecological and evolutionary processes.Parasitology · 2021Article
- Evidence for reduced immune gene diversity and activity during the evolution of termites.Proceedings. Biological sciences · 2021Article
- Genome-wide patterns of differentiation within and among U.S. commercial honey bee stocks.BMC genomics · 2020Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social organisms combat pathogens through individual innate immune responses or through social immunity-behaviors among individuals that limit pathogen transmission within groups. Although we have a relatively detailed understanding of the genetics and evolution of the innate immune system of animals, we know little about social immunity. Addressing this knowledge gap is crucial for understanding how life-history traits influence immunity, and identifying if trade-offs exist between innate and social immunity. Hygienic behavior in the Western honey bee, Apis mellifera, provides an excellent model for investigating the genetics and evolution of social immunity in animals. This heritable, colony-level behavior is performed by nurse bees when they detect and remove infected or dead brood from the colony. We sequenced 125 haploid genomes from two artificially selected highly hygienic populations and a baseline unselected population. Genomic contrasts allowed us to identify a minimum of 73 genes tentatively associated with hygienic behavior. Many genes were within previously discovered QTLs associated with hygienic behavior and were predictive of hygienic behavior within the unselected population. These genes were often involved in neuronal development and sensory perception in solitary insects. We found that genes associated with hygienic behavior have evidence of positive selection within honey bees (Apis), supporting the hypothesis that social immunity contributes to fitness. Our results indicate that genes influencing developmental neurobiology and behavior in solitary insects may have been co-opted to give rise to a novel and adaptive social immune phenotype in honey bees.
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