ArticleOncology nursing forum2019
Childhood Cancer Symptom Cluster: Leukemia and Health-Related Quality of Life.
Article in Oncology nursing forum, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of digital health on symptoms and health-related quality of life in children and adolescent cancer survivors: a meta-analysis and systematic review.Journal of cancer survivorship : research and practice · 2026Pooled it
- Prevalence of symptoms in children with acute lymphoblastic leukaemia: a systematic review and meta-analysis.BMC cancer · 2023Pooled it
- Cognitive-Behavioral Intervention for Children With Hematological Cancer Receiving Chemotherapy: A Randomized Controlled Trial.Psycho-oncology · 2025Trial
- Factors influencing health-related quality of life in children with leukemia in Saudi Arabia: a cross- sectional study.BMC pediatrics · 2026Article
- Caregivers' Perspectives on Changes in Family Life During B-ALL Therapy: A Qualitative Study From the Children's Oncology Group.Pediatric blood & cancer · 2025Article
- Evaluating Sleep in Pediatric Cancer: A Scoping Review of Assessment Tools for Quality and Care.Cancer medicine · 2025Article
- Cancer Symptom Clusters in Children and Adolescents with Cancer Undergoing Chemotherapy: A Systematic Review.Nursing reports (Pavia, Italy) · 2025Review
- Multi-omics analysis of the gut microbiome and metabolites associated with the psychoneurological symptom cluster in children with cancer receiving chemotherapy.Journal of translational medicine · 2024Article
- Effects of Child Life intervention on the symptom cluster of pain-anxiety-fatigue-sleep disturbance in children with acute leukemia undergoing chemotherapy.Asia-Pacific journal of oncology nursing · 2023Article
- Establishing nursing-sensitive quality indicators for pediatric oncology: An international mixed methods Delphi study.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2023Article
- Lived experiences with unmet supportive care needs in pediatric cancer: Perspective of Chinese children and their parents.International journal of nursing sciences · 2022Article
- Targeting Redox Regulation as a Therapeutic Opportunity against Acute Leukemia: Pro-Oxidant Strategy or Antioxidant Approach?Antioxidants (Basel, Switzerland) · 2022Review
- The Development of an mHealth Tool for Children With Long-term Illness to Enable Person-Centered Communication: User-Centered Design Approach.JMIR pediatrics and parenting · 2022Article
- Prospective patient-reported symptom profiles associated with pediatric acute lymphoblastic leukemia relapse.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Systematic Review on the Use of the Children's Depression Inventory-2 among Hispanics.Hispanic journal of behavioral sciences · 2020Article
- Relationships Between Parental Anxiety and Child Quality of Life in Advanced Childhood Cancer.Journal of pediatric hematology/oncology nursingArticle
- Article
- The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology NursesArticle
- Symptom Adverse Events and Quality of Life of Children With Advanced Cancer: Results From a Longitudinal Study Using the Pediatric Patient-Reported Outcomes-Common Terminology Criteria for Adverse Events.Journal of pediatric hematology/oncology nursingArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectivesTo examine the relationship of the Childhood Cancer Symptom Cluster-Leukemia (CCSC-L) with health-related quality of life (HRQOL). SAMPLE &
setting327 children receiving treatment for acute lymphoblastic leukemia from four pediatric oncology programs across the United States. METHODS & VARIABLES: Participants completed fatigue, sleep disturbance, pain, nausea, and depression symptom questionnaires at four time points; these symptoms comprised the CCSC-L. HRQOL was measured at the start of postinduction therapy and then at the start of maintenance therapy. Relationships between the CCSC-L and HRQOL scores were examined with longitudinal parallel-process modeling.
resultsThe mean HRQOL significantly increased over time (p < 0.001). The CCSC-L had a significant negative association with HRQOL scores at the start of postinduction therapy (beta = -0.53, p < 0.005) and the start of maintenance therapy (beta = -0.33, p < 0.015). Participants with more severe symptoms in the CCSC-L over time had significantly lower HRQOL at the start of maintenance therapy (beta = -0.42, p < 0.005). IMPLICATIONS FOR NURSING: Nurses are pivotal in providing management strategies to minimize symptom severity that may improve HRQOL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.