Evidence map›Paper›PMID 30767942›Full record

ArticleJournal of neurosurgical anesthesiology2019

A Summary of Preclinical Poster Presentations at the Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) Symposium.

Keren K Griffiths, Philip G Morgan, Simon C Johnson, Pratheeban Nambyiah, Sulpicio G Soriano, Kenneth Johnson, Jing Xu, Carol Garber, Lynne Maxwell, Neeta Saraiya

Abstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurosurgical anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keren K GriffithsDepartment of Anesthesiology.
Philip G MorganDepartment of Anesthesiology, University of Washington.
Simon C JohnsonCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA.
Pratheeban NambyiahMRC London Institute of Medical Sciences, Imperial College, London, UK.
Sulpicio G SorianoDepartment of Anesthesia, Harvard Medical School, Boston, MA.
Kenneth JohnsonWeill Cornell Medicine, New York, NY.
Jing XuDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Carol GarberDepartment of Bio-behavioral Sciences, Teacher's College, Columbia University.
Lynne MaxwellDepartment of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Neeta SaraiyaDepartment of Anesthesiology.

Funding

ANESTHESIOLOGY RESEARCH TRAININGT32GM008464 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHARLES W EMALA, May Hua · 1992 to 2026
$6.0M
Anesthetic neurotoxicity is controlled by ER-stressR01GM118514 · NIGMS · SEATTLE CHILDREN'S HOSPITAL · PI MORGAN, PHILIP G · 2017 to 2020
$1.5M
NIGMS NIH HHS R01 GM118514NIGMS NIH HHS T32 GM008464
6 · The paper itself

Abstract

The potential for long-term neurotoxic effects of anesthetics on the developing human brain has led to intensified research in this area. To date, the human evidence has been inconclusive, but a large body of animal evidence continues to demonstrate cause for concern. On April 14 and 15, 2018 the sixth biennial Pediatric Anesthesia and Neurodevelopmental Assessment (PANDA) study symposium was held at Morgan Stanley Children's Hospital of New York. This symposium brought together clinicians and researchers and served as a platform to review preclinical and clinical data related to anesthesia and neurotoxicity in developing brains. The program participants included many active investigators in the field of anesthesia neurotoxicity as well as stakeholders from different backgrounds with the common interest of potential anesthetic neurotoxicity in children. The moderated poster session included presentations of preclinical animal research studies. These studies focused on defining the anesthetic-induced neurotoxicity phenotype, understanding the mechanism of injury and discovering potential inhibitors of neurotoxic effects.

Indexed as

AdolescentAnesthesiaAnestheticsAnimalsChildChild, PreschoolDevelopmental DisabilitiesHumansInfantInfant, NewbornNeurotoxicity SyndromesAnesthetics

Identifiers

PMID30767942
PMCPMC7959115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.