ArticleeLife2019
A Y-chromosome shredding gene drive for controlling pest vertebrate populations.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Y-linked editors for invasive rodent control.Molecular biology and evolution · 2026Article
- Non-Mendelian transmission of X chromosomes: mechanisms and impact on sex ratios and population dynamics in different breeding systems.Biochemical Society transactions · 2024Review
- Investigating the potential of X chromosome shredding for mouse genetic biocontrol.Scientific reports · 2024Article
- Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter.PLoS genetics · 2024Article
- Next-generation CRISPR gene-drive systems using Cas12a nuclease.Nature communications · 2023Article
- Leveraging a natural murine meiotic drive to suppress invasive populations.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Gene drives for vertebrate pest control: Realistic spatial modelling of eradication probabilities and times for island mouse populations.Molecular ecology · 2022Article
- Gene Editing and Genetic Control of Hemipteran Pests: Progress, Challenges and Perspectives.Frontiers in bioengineering and biotechnology · 2022Review
- Single nucleotide polymorphism (SNP) in theWellcome open research · 2022Article
- Gene drives gaining speed.Nature reviews. Genetics · 2022Review
- Modeling CRISPR gene drives for suppression of invasive rodents using a supervised machine learning framework.PLoS computational biology · 2021Article
- Article
- Hidden genomic features of an invasive malaria vector, Anopheles stephensi, revealed by a chromosome-level genome assembly.BMC biology · 2021Article
- Polyandry blocks gene drive in a wild house mouse population.Nature communications · 2020Article
- Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex.Annual review of ecology, evolution, and systematics · 2020Article
- Resistance to natural and synthetic gene drive systems.Journal of evolutionary biology · 2020Review
- The potential for a CRISPR gene drive to eradicate or suppress globally invasive social wasps.Scientific reports · 2020Article
- Genetic Biocontrol for Invasive Species.Frontiers in bioengineering and biotechnology · 2020Review
- Mathematical modeling of self-contained CRISPR gene drive reversal systems.Scientific reports · 2019Article
- Rodent gene drives for conservation: opportunities and data needs.Proceedings. Biological sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could be incorporated within gene-drive designs. We introduce a novel gene-drive strategy termed Y-CHromosome deletion using Orthogonal Programmable Endonucleases (Y-CHOPE), incorporating a programmable endonuclease that 'shreds' the Y chromosome, thereby converting XY males into fertile XO females. Firstly, we demonstrate that the CRISPR/Cas12a system can eliminate the Y chromosome in embryonic stem cells with high efficiency (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.