Evidence map›Paper›PMID 30767759›Full record

ArticleCurrent aging science2019

Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama.

Gabrielle B Britton, Sid E O'Bryant, Leigh A Johnson, James R Hall, Alcibiades E Villarreal, Diana C Oviedo, Ambar R Pérez-Lao, María B Carreira

Open access · hybridAbstract read
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Article in Current aging science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Gabrielle B BrittonNeurosciences Center and Clinical Research Unit, Institute of Scientific Research and High Technology Services (INDICASAT AIP), City of Knowledge, Panama.
Sid E O'BryantUniversity of North Texas Health Science Center, Department of Pharmacology & Neuroscience, Fort Worth, TX, United States.
Leigh A JohnsonUniversity of North Texas Health Science Center, Department of Pharmacology & Neuroscience, Fort Worth, TX, United States.
James R HallUniversity of North Texas Health Science Center, Department of Pharmacology & Neuroscience, Fort Worth, TX, United States.
Alcibiades E VillarrealNeurosciences Center and Clinical Research Unit, Institute of Scientific Research and High Technology Services (INDICASAT AIP), City of Knowledge, Panama.
Diana C OviedoDepartment of Psychology, Santa María La Antigua Catholic University, Panama, Panama.
Ambar R Pérez-LaoDepartment of Psychology, Santa María La Antigua Catholic University, Panama, Panama.
María B CarreiraNeurosciences Center and Clinical Research Unit, Institute of Scientific Research and High Technology Services (INDICASAT AIP), City of Knowledge, Panama.
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología · PAUniversity of North Texas · USUniversidad Católica Santa María La Antigua · PA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFalls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality.

objectiveThe objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults.

methodData were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events.

resultsDepressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls.

conclusionThere is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.

Indexed as

Accidental FallsAgedAged, 80 and overAgingBiomarkersChemokine CCL1C-Reactive ProteinDepressionFemaleHispanic or LatinoHumansIncidenceInflammation MediatorsInterleukin-10Interleukin-6Interleukin-7BiomarkersCCL1 protein, humanChemokine CCL1C-Reactive ProteinIL10 protein, humanIL6 protein, humanIL7 protein, humanInflammation MediatorsInterleukin-10Interleukin-6Interleukin-7AgingdepressiondisabilityHispanicsinflammation.Latin America

Identifiers

PMID30767759
PMCPMC6635419
OpenAlexW2914552285

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.