ArticleNeuropsychopharmacology reports2019
Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice.
Article in Neuropsychopharmacology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 9 citations in OpenAlex.
- Multiomic profiling of the acute stress response in the mouse hippocampus.Nature communications · 2022Article
- Stress-induced sleep-like inactivity modulates stress susceptibility in mice.Scientific reports · 2020Article
- Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex.Scientific reports · 2019Article
- Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice.Neuropsychopharmacology reports · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimsAnimal studies using various stress models have shown that excessive environmental stress induces depression? and anxiety?like behaviors through inflammatory responses in the brain and periphery. Although the leptomeningeal cells have multiple functions related to inflammatory responses in the brain, whether environmental stress influences the leptomeninges remains unknown. In this study, we aimed to examine phosphorylation of the extracellular signal-regulated kinase (ERK) in the leptomeninges.
methodsWe subjected C57BL/6 male mice to a single episode of social defeat stress and analyzed the expression of phosphorylated ERK in the leptomeninges by immunohistochemistry.
resultsSocial defeat stress in mice induced phosphorylation of ERK in the leptomeninges, adjacent to vascular endothelial cells and the glia limitans. This ERK phosphorylation was maintained for at least one hour after the stress.
conclusionsThis study shows the effect of environmental stress on the leptomeninges for the first time and paves the way for elucidating its functional role in stress-induced changes in neural functions.
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