ArticleJournal of biophotonics2019
An optical study of drug resistance detection in endometrial cancer cells by dynamic and quantitative phase imaging.
Article in Journal of biophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Drug-resistant profiles of extracellular vesicles predict therapeutic response in TNBC patients receiving neoadjuvant chemotherapy.BMC cancer · 2024Article
- Involvement of cell shape and lipid metabolism in glioblastoma resistance to temozolomide.Acta pharmacologica Sinica · 2023Article
- Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer.Communications biology · 2022Article
- Quantitative scoring of epithelial and mesenchymal qualities of cancer cells using machine learning and quantitative phase imaging.Journal of biomedical optics · 2020Article
- Simple adaptive mobile phone screen illumination for dual phone differential phase contrast (DPDPC) microscopy.Biomedical optics express · 2019Article
- An optical study of drug resistance detection in endometrial cancer cells by dynamic and quantitative phase imaging.Journal of biophotonics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Platinum chemosensitivity detection plays a vital role during endometrial cancer treatment because chemotherapy responses have profound influences on patient's prognosis. Although several methods can be used to detect drug resistance characteristics, studies on detecting drug sensitivity based on dynamic and quantitative phase imaging of cancer cells are rare. In this study, digital holographic microscopy was applied to distinguish drug-resistant and nondrug-resistant endometrial cancer cells. Based on the reconstructed phase images, temporal evolutions of cell height (CH), cell projected area (CPA) and cell volume were quantitatively measured. The results show that change rates of CH and CPA were significantly different between drug-resistant and nondrug-resistant endometrial cancer cells. Furthermore, the results demonstrate that morphological characteristics have the potential to be utilized to distinguish the drug sensitivity of endometrial cancer cells, and it may provide new perspectives to establish optical methods to detect drug sensitivity and guide chemotherapy in endometrial cancer.
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Registered trials
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