Evidence map›Paper›PMID 30767345›Full record

ArticleJournal of applied microbiology2019

The use of laser-based diagnostics for the rapid identification of infectious agents in human blood.

R A Multari, D A Cremers, A Nelson, Z Karimi, S Young, C Fisher, R Duncan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

R A MultariCreative LIBS Solutions, Bernalillo, NM, USA.ORCID http://orcid.org/0000-0002-0685-0191
D A CremersCreative LIBS Solutions, Bernalillo, NM, USA.
A NelsonCreative LIBS Solutions, Bernalillo, NM, USA.
Z KarimiTriCore Reference Laboratories, Albuquerque, NM, USA.
S YoungTriCore Reference Laboratories, Albuquerque, NM, USA.
C FisherFood and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD, USA.
R DuncanFood and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0001-8409-2501

Funding

Development of a Laser-Based Technology for Rapid Point of Care Diagnosis of Blood-borne InfectionsR43HL133525 · NHLBI · CREATIVE LIBS SOLUTIONS, LLC · PI CREMERS, DAVID ALLEN, MULTARI, ROSALIE A · 2016 to 2016
$150k
National Institutes of Health 1R43HL133525-01NHLBI NIH HHS R43 HL133525
6 · The paper itself

Abstract

aimsTo investigate the use of a laser-based method of detection as a potential diagnostic test for the rapid identification of infectious agents in human blood. METHODS AND

resultsIn this study, the successful differentiation of blood spiked with viruses, bacteria or protozoan parasites to clinically relevant levels is demonstrated using six blood types (O+, O-, AB+, A+, A-, B+) using blood from different individuals with blood samples prepared in two different laboratories. Experiments were performed using various compositions of filters, experimental set-ups and experimental parameters for spectral capture.

conclusionsThe potential for developing a laser-based diagnostic instrument to detect the presence of parasites, bacteria and viruses in human blood capable of providing analysis results within minutes was demonstrated. SIGNIFICANCE AND IMPACT OF THE STUDY: There is an ongoing need for clinical diagnostics to adapt to newly emerging agents and to screen simultaneously for multiple infectious agents. A laser-based approach can achieve sensitive, multiplex detection with minimal sample preparation and provide rapid results (within minutes). These properties along with the flexibility to add new agent detection by simply adjusting the detection programming make it a promising tool for clinical diagnosis.

Indexed as

LasersSepsisABO Blood-Group SystemHumansMicrobiological TechniquesABO Blood-Group SystembloodHIVlaserLIBSrapidStaphylococcus aureusTrypanosoma cruzi

Identifiers

PMID30767345
PMCPMC6458062

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.