Evidence map›Paper›PMID 30767211›Full record

ArticleBritish journal of haematology2019

Combination lenalidomide-rituximab immunotherapy activates anti-tumour immunity and induces tumour cell death by complementary mechanisms of action in follicular lymphoma.

Hsiling Chiu, Preeti Trisal, Chad Bjorklund, Soraya Carrancio, Estela G Toraño, Carla Guarinos, Despoina Papazoglou, Patrick R Hagner, Asma Beldi-Ferchiou, Karin Tarte and 4 more

Open access · hybridAbstract read
In one paragraph

Article in British journal of haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

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  17. Immunomodulatory Drugs for the Treatment of B Cell Malignancies.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Hsiling ChiuCelgene Corporation, Summit, NJ, USA.
Preeti TrisalCelgene Corporation, Summit, NJ, USA.
Chad BjorklundCelgene Corporation, Summit, NJ, USA.
Soraya CarrancioCelgene Corporation, San Diego, CA, USA.
Estela G TorañoCelgene Institute for Translational Research Europe, Seville, Spain.
Carla GuarinosCelgene Institute for Translational Research Europe, Seville, Spain.
Despoina PapazoglouSchool of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Patrick R HagnerCelgene Corporation, Summit, NJ, USA.ORCID 0000-0002-8577-0105
Asma Beldi-FerchiouDepartment of Immunobiology and Haematobiology, CHU Henri Mondor, Créteil, France.
Karin TarteSITI laboratory, CHU Rennes, UMR, U1236 University of Rennes, INSERM, EFS, Rennes, France.
Marie-Hélène Delfau-LarueDepartment of Immunobiology and Haematobiology, CHU Henri Mondor, Créteil, France.
Franck MorschhauserUniversité de Lille/Hôpital Claude Huriez, Lille, France.
Alan G RamsaySchool of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Anita K GandhiCelgene Corporation, Summit, NJ, USA.ORCID 0000-0001-5512-1625
Centre Hospitalier Universitaire Henri-Mondor · FRKing's College London · GBInserm · FRUniversité de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy plus rituximab has been the mainstay of treatment for follicular lymphoma (FL) for two decades but is associated with immunosuppression and relapse. In phase 2 studies, lenalidomide combined with rituximab (R

Indexed as

Antibody-Dependent Cell CytotoxicityAntineoplastic Combined Chemotherapy ProtocolsB-LymphocytesCD8-Positive T-LymphocytesCell ProliferationCyclophosphamideCytokinesDoxorubicinDrug Resistance, NeoplasmHumansImmunological SynapsesImmunotherapyKiller Cells, NaturalLenalidomideLymphocyte ActivationLymphocyte CountCyclophosphamideCytokinesDoxorubicinLenalidomidePrednisoneR-CHOP protocolRituximabVincristineantibody-dependent cell-mediated cytotoxicityfollicular lymphomaimmunomodulationlenalidomidenon-Hodgkin lymphoma

Identifiers

PMID30767211
PMCPMC6594227
OpenAlexW2915026453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.